Epidermal growth factor receptor (EGFR) inhibitor-induced rash: a consecutive patient series that illustrates the need for rigorous palliative trials.
Epidermal growth factor receptor (EGFR) inhibitor-induced rash: a consecutive patient series that illustrates the need for rigorous palliative trials.
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表皮生长因子受体 (EGFR) 抑制剂诱发的皮疹：连续的患者系列表明需要进行严格的姑息治疗试验。
DOI：
10.1089/jpm.2010.0258
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发表时间：
2011
影响因子：
2.8
通讯作者：
Jatoi,Aminah
中科院分区：
文献类型：
--
作者：
Solomon,BenjaminM;Jatoi,Aminah
Purpose:Rash is the most common side effect of epidermal growth factor receptor (EGFR) inhibitors and negatively impacts quality of life. This single-institution study sought to explore how rash is currently managed outside a clinical trial setting and to further characterize general clinical aspects of this rash.Methods/Results:Among 4101 consecutive patients with cancer of the lung, colorectum, pancreas, and head and neck, 138 had received an EGFR inhibitor. Within this group, 96 (69%) developed a rash. Forty-nine of these patients were prescribed rash therapy, and a total of 26 different palliative regimens were used. Surprisingly, most patients, with the exception of 2, appear to have manifested evidence of rash improvement—even when unproven or disproved therapies had been prescribed. Fourteen patients stopped their EGFR inhibitor because of rash, and 11 were then able to restart. No demographic variables were able to predict rash development.Conclusion:The observation that multiple, largely unproven, anecdotal therapies are being prescribed to palliate EGFR inhibitor-induced rashes underscores the need for more rigorous, prospective palliative trials.
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EGFR 抑制剂引起的皮疹：姑息治疗的机遇和挑战
影响因子：
4.7
作者：
B. Solomon;A. Jatoi
通讯作者：
A. Jatoi
影响因子：
45.3
作者：
D. Gallagher;N. Kemeny
通讯作者：
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DOI：
10.1200/jco.2002.20.2.362
发表时间：
2002
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
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作者：
A. Jatoi;C. Loprinzi
通讯作者：
C. Loprinzi
DOI：
10.3747/co.v16i4.469
发表时间：
2009-08
期刊：
Current oncology (Toronto, Ont.)
影响因子：
--
作者：
Dent S;Verma Sh;Latreille J;Rayson D;Clemons M;Mackey J;Verma S;Lemieux J;Provencher L;Chia S;Wang B;Pritchard K
通讯作者：
Pritchard K
影响因子：
3.1
作者：
Gandhi, Mona;Oishi, Karen;Lacouture, Mario E.
通讯作者：
Lacouture, Mario E.