C-reactive protein as a biomarker of severe H1N1 influenza.
C-reactive protein as a biomarker of severe H1N1 influenza.
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DOI：
10.1007/s00011-018-1188-x
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Badawi A
中科院分区：
文献类型：
--
作者：
Vasileva D;Badawi A
C反应蛋白（CRP）是流感感染期间释放的促炎细胞因子下游的急性相反应物。然而，这种炎症标志物在流感严重程度和并发症中的作用尚未阐明。我们的目标是系统地审查和评估严重和非严重 H1N1 流感病例中的 CRP 水平，并评估其作为预测感染严重程度的生物标志物的效用。我们在 Print、Embase 和 Embase Classic 之前在 Ovid MEDLINE、Ovid MEDLINE (R) Epub 中进行了全面检索，以确定报告感染不同疾病严重程度的 H1N1 流感患者 CRP 水平测量结果的人类研究。我们的搜索确定了十项有资格纳入本系统评价的研究。数据分析结果显示，与非重症患者相比，重症 H1N1 流感患者诊断时的平均 CRP 水平显着较高（P<0.05）。此外，CRP 水平与 H1N1 流感的严重程度相关。患有 H1N1 相关肺炎的受试者和因疾病并发症住院或死亡的患者的 CRP 水平分别比无严重疾病结果的患者显着升高 1.4 倍和 2.5 倍（P<0.05）。研究一致表明，出现严重疾病结果的 H1N1 流感患者的 CRP 水平显着较高。本研究的结果表明，血清 CRP 可以与其他生物标志物结合使用来预测 H1N1 流感的并发症。本文的在线版本 (10.1007/s00011-018-1188-x) 包含补充材料，可供授权用户使用。
C-reactive protein (CRP) is an acute-phase reactant downstream of the pro-inflammatory cytokines released during influenza infection. However, the role of this inflammatory marker in influenza severity and complications is yet to be elucidated. We aim to systematically review and evaluate the levels of CRP in severe and non-severe H1N1 influenza cases and assess its utility as a biomarker in predicting the severity of infection. We conducted a comprehensive search in Ovid MEDLINE, Ovid MEDLINE (R) Epub ahead of Print, Embase and Embase Classic to identify human studies reporting measurements of CRP levels in patients infected with H1N1 influenza at various levels of disease severity. Our search identified ten studies eligible for inclusion in this systematic review. The results of the data analysis show that the average CRP levels upon diagnosis were significantly higher (P < 0.05) in patients who developed severe H1N1 influenza compared to their counterparts with a no severe disease. Furthermore, levels of CRP were associated with the degree of H1N1 severity. Subjects with H1N1-related pneumonia and patients who were hospitalized or died of the disease complications, respectively, had 1.4- and 2.5-fold significantly higher CRP levels (P < 0.05) than those with no severe disease outcome. CRP levels have been consistently shown to be significantly higher in H1N1 influenza patients who develop a severe disease outcome. The resuts of the present study suggest that serum CRP can be employed—in combination with other biomarkers—to predict the complications of H1N1 influenza. The online version of this article (10.1007/s00011-018-1188-x) contains supplementary material, which is available to authorized users.
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