Pandemic influenza A/H1N1 virus infection and TNF, LTA, IL1B, IL6, IL8, and CCL polymorphisms in Mexican population: a case-control study.
Pandemic influenza A/H1N1 virus infection and TNF, LTA, IL1B, IL6, IL8, and CCL polymorphisms in Mexican population: a case-control study.
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DOI：
10.1186/1471-2334-12-299
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发表时间：
2012-11-13
影响因子：
3.7
通讯作者：
Mejía-Aranguré JM
中科院分区：
文献类型：
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作者：
Morales-García G;Falfán-Valencia R;García-Ramírez RA;Camarena Á;Ramirez-Venegas A;Castillejos-López M;Pérez-Rodríguez M;González-Bonilla C;Grajales-Muñíz C;Borja-Aburto V;Mejía-Aranguré JM
一些患者对病毒感染的反应比具有相似病毒复制水平的其他患者更强。高细胞因子血症是导致 A/H1N1 流感病例出现更严重临床病程的主要免疫病理学机制。这些细胞因子在严重疾病中产生的益处或造成的损害尚不清楚。编码这些分子的基因是多态性的，某些等位基因与各种疾病的易感性有关。本研究的目的是确定 TNF、LTA、IL1B、IL6、IL8 和 CCL1 的多态性与 2009 年墨西哥甲型 H1N1 流感大流行引起的感染和疾病严重程度之间是否存在关联。病例对照研究。这些病例是经实时PCR确诊感染甲型H1N1流感病毒的患者。对照组为流感样感染患者和流感患者的非家庭健康接触者。记录疾病的病史和结果。对 DNA 样本进行 TNF rs361525、rs1800629 和 rs1800750 多态性基因分型； LTA rs909253； IL1B rs16944; IL6 rs1818879; IL8 rs4073;和 CCL1 rs2282691。计算优势比 (OR) 和 95% 置信区间 (95% CI)。根据病例的年龄和疾病严重程度对逻辑回归模型进行调整。大流行 A/H1N1 病毒感染与以下基因型相关：TNF rs361525 AA，OR = 27.00； 95% CI = 3.07–1248.77)； LTA rs909253 AG（OR = 4.33，95% CI = 1.82–10.32）； TNF rs1800750 AA（OR = 4.33，95% CI = 1.48–12.64）；此外，LTA rs909253 AG 显示与死亡率之间存在有限的统计显着相关性（p = 0.06，OR = 3.13）。 TNF rs1800629 GA 基因型携带者与高水平的血液尿素氮相关（p = 0.05）； TNF rs1800750 AA 基因型，具有高水平的肌酸磷酸激酶 (p=0.05)。 IL1B rs16944 AA 基因型与白细胞数量升高相关 (p <0.001)，IL8 rs4073 AA 基因型与 PaO2 mm Hg 值较高相关。参与炎症过程的基因多态性导致了大流行性甲型H1N1流感病毒感染临床行为的严重性。
Some patients have a greater response to viral infection than do others having a similar level of viral replication. Hypercytokinemia is the principal immunopathological mechanism that contributes to a severer clinical course in cases of influenza A/H1N1. The benefit produced, or damage caused, by these cytokines in severe disease is not known. The genes that code for these molecules are polymorphic and certain alleles have been associated with susceptibility to various diseases. The objective of the present study was to determine whether there was an association between polymorphisms of TNF, LTA, IL1B, IL6, IL8, and CCL1 and the infection and severity of the illness caused by the pandemic A/H1N1 in Mexico in 2009. Case–control study. The cases were patients confirmed with real time PCR with infection by the A/H1N1 pandemic virus. The controls were patients with infection like to influenza and non-familial healthy contacts of the patients with influenza. Medical history and outcome of the disease was registered. The DNA samples were genotyped for polymorphisms TNF rs361525, rs1800629, and rs1800750; LTA rs909253; IL1B rs16944; IL6 rs1818879; IL8 rs4073; and CCL1 rs2282691. Odds ratio (OR) and the 95% confidence interval (95% CI) were calculated. The logistic regression model was adjusted by age and severity of the illness in cases. Infection with the pandemic A/H1N1 virus was associated with the following genotypes: TNF rs361525 AA, OR = 27.00; 95% CI = 3.07–1248.77); LTA rs909253 AG (OR = 4.33, 95% CI = 1.82–10.32); TNF rs1800750 AA (OR = 4.33, 95% CI = 1.48–12.64); additionally, LTA rs909253 AG showed a limited statistically significant association with mortality (p = 0.06, OR = 3.13). Carriers of the TNF rs1800629 GA genotype were associated with high levels of blood urea nitrogen (p = 0.05); those of the TNF rs1800750 AA genotype, with high levels of creatine phosphokinase (p=0.05). The IL1B rs16944 AA genotype was associated with an elevated number of leukocytes (p <0.001) and the IL8 rs4073 AA genotype, with a higher value for PaO2 mm Hg. The polymorphisms of genes involved in the inflammatory process contributed to the severity of the clinical behavior of infection by the pandemic influenza A/H1N1 virus.
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影响因子：
5.8
作者：
Qi, Lu;Zhang, Cuilin;Hu, Frank B.
通讯作者：
Hu, Frank B.
影响因子：
5.3
作者：
Gaudet, Mia M.;Egan, Kathleen M.;Garcia-Closas, Montserrat
通讯作者：
Garcia-Closas, Montserrat
影响因子：
168.9
作者：
Echevarria-Zuno, Santiago;Manuel Mejia-Arangure, Juan;Hugo Borja-Aburto, Victor
通讯作者：
Hugo Borja-Aburto, Victor
DOI：
10.1186/cc8208
发表时间：
2009
期刊：
Critical care (London, England)
影响因子：
--
作者：
Bermejo-Martin JF;Ortiz de Lejarazu R;Pumarola T;Rello J;Almansa R;Ramírez P;Martin-Loeches I;Varillas D;Gallegos MC;Serón C;Micheloud D;Gomez JM;Tenorio-Abreu A;Ramos MJ;Molina ML;Huidobro S;Sanchez E;Gordón M;Fernández V;Del Castillo A;Marcos MA;Villanueva B;López CJ;Rodríguez-Domínguez M;Galan JC;Cantón R;Lietor A;Rojo S;Eiros JM;Hinojosa C;Gonzalez I;Torner N;Banner D;Leon A;Cuesta P;Rowe T;Kelvin DJ
通讯作者：
Kelvin DJ
影响因子：
11.8
作者：
Papenburg, Jesse;Baz, Mariana;Boivin, Guy
通讯作者：
Boivin, Guy