Preclinical Studies of Stem Cell Transplantation in Intracerebral Hemorrhage: a Systemic Review and Meta-Analysis.
Preclinical Studies of Stem Cell Transplantation in Intracerebral Hemorrhage: a Systemic Review and Meta-Analysis.
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干细胞移植治疗脑出血的临床前研究：系统评价和荟萃分析
DOI：
10.1007/s12035-015-9441-6
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发表时间：
2016-10
影响因子：
5.1
通讯作者：
Tang Z
中科院分区：
文献类型：
--
作者：
Hu Y;Liu N;Zhang P;Pan C;Zhang Y;Tang Y;Deng H;Aimaiti M;Zhang Y;Zhou H;Wu G;Tang Z
为了全面评估干细胞治疗对功能和结构结果的影响，我们对干细胞治疗颅内出血的临床前数据进行了荟萃分析，从而为临床翻译提供了最佳的证据和指导。我们搜索了在线数据库，以确定基于未经修改的干细胞移植治疗颅内出血(ICH)的合格研究。从每项研究中，我们提取了关于神经行为和组织学结果的数据，以便根据最重要的临床参数(7个指数)分析综合有效大小，并通过Meta回归来探索任何潜在的相关性。我们分析了40项符合条件的研究，包括1021只动物，发现行为和结构结果都有显著改善，修改的神经严重程度评分的中位数效应值为1.77，改进的放置测试的中位数效应值为1.16，旋转棒测试的中位数效应值为1.82，组织丢失减少的中位数效应值为1.24。Meta回归结果显示，脑内给药对脑出血后的行为和结构恢复最有效；间充质干细胞的治疗效果与神经干细胞相似。延迟治疗在脑出血后一周多应用，显示出结构结果的最大改善。干细胞治疗对脑出血动物的行为和结构结果有显著的改善作用，其作用大小相对较大。然而，考虑到较差的研究质量和不可忽视的发表偏见，该疗法的实际疗效可能会较低。此外，未来的研究应该谨慎地解释动物结果，因为在涉及动物研究和临床试验的设计时，内部和外部有效性有限。本文的在线版本(doi：10.1007/s12035-015-9441-6)包含补充材料，授权用户可以使用。
To comprehensively evaluate the therapeutic effects on both functional and structural outcomes, we performed a meta-analysis of preclinical data on stem cell therapy in intracranial hemorrhage, thus providing optimal evidence and instruction for clinical translation. We searched online databases to identify eligible studies based on unmodified stem cell transplantation in intracranial hemorrhage (ICH). From each study, we extracted data regarding neurobehavioral and histological outcomes in order to analyze the comprehensive effective sizes according to the most important clinical parameters (seven indices) and to explore any potential correlation through meta-regression. We analyzed 40 eligible studies including 1021 animals and found a significant improvement in both behavioral and structural outcomes with the median effect size of 1.77 for modified Neurological Severity Score, 1.16 for the modified placement test, 1.82 for the rotarod test, and 1.24 for tissue loss reduction. The meta-regression results revealed that intracerebral administration was the most effective for behavioral and structural recovery post-ICH; mesenchymal stem cells shared comparable therapeutic effects with neural stem cells. Delayed therapy, applied more than 1 week after ICH, showed the greatest improvement of structural outcomes. Stem cell therapy showed significant improvement on behavioral and structural outcomes of ICH animals with relatively large effect sizes. However, the practical efficacy of the therapy is likely to be lower considering poor study quality and non-negligible publication bias. Further, future research should interpret animal results cautiously considering the limited internal and external validity when referring to the design of both animal studies and clinical trials. The online version of this article (doi:10.1007/s12035-015-9441-6) contains supplementary material, which is available to authorized users.
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影响因子：
23.9
作者：
Caplan AI;Correa D
通讯作者：
Correa D
影响因子：
3.3
作者：
Chopp M;Steinberg GK;Kondziolka D;Lu M;Bliss TM;Li Y;Hess DC;Borlongan CV
通讯作者：
Borlongan CV
影响因子：
14.5
作者：
Lee, Soon-Tae;Chu, Kon;Roh, Jae-Kyu
通讯作者：
Roh, Jae-Kyu
影响因子：
8.3
作者：
Fisher M;Feuerstein G;Howells DW;Hurn PD;Kent TA;Savitz SI;Lo EH;STAIR Group
通讯作者：
STAIR Group
DOI：
10.1093/brain/awr339
发表时间：
2012-02
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Cusimano M;Biziato D;Brambilla E;Donegà M;Alfaro-Cervello C;Snider S;Salani G;Pucci F;Comi G;Garcia-Verdugo JM;De Palma M;Martino G;Pluchino S
通讯作者：
Pluchino S