Antigen-specific T lymphocytes regulate lipopolysaccharide-induced apoptosis of dendritic cells in vivo.
Antigen-specific T lymphocytes regulate lipopolysaccharide-induced apoptosis of dendritic cells in vivo.
复制标题
抗原特异性 T 淋巴细胞在体内调节脂多糖诱导的树突状细胞凋亡。
DOI：
10.4049/jimmunol.161.9.4476
复制
发表时间：
1998
影响因子：
4.4
通讯作者：
M. Moser
中科院分区：
文献类型：
--
作者：
T. D. Smedt;B. Pajak;G. Klaus;R. Noelle;J. Urbain;O. Leo;M. Moser
树突状细胞 (DC) 的有效辅助特性在称为“成熟”的过程中依次发展。脾 DC 响应细菌产物 LPS 在体内经历功能成熟，并从边缘区迁移到 T 细胞区域。完全成熟的 DC（其呈现在 T 细胞区域的外周遇到的 Ag）的重新分布可能会导致 T 细胞启动。出乎意料的是，我们发现DC一旦进入T细胞区就会迅速凋亡。在 OVA 特异性 TCR 转基因小鼠中注射 OVA 肽可强烈延迟 LPS 诱导的 DC 原位细胞凋亡。我们得出的结论是，成熟的 DC 除非收到来自 T 细胞的生存信号，否则会被编程死亡，并且 DC 生存的调节可能是一种旨在控制免疫反应的启动和终止的机制。
The potent accessory properties of dendritic cells (DC) develop sequentially during a process termed "maturation." Splenic DC undergo functional maturation in vivo in response to the bacterial product LPS and migrate from the marginal zone to the T cell areas. The redistribution of fully mature DC, which present Ags encountered in the periphery, in the T cell area is likely to result in T cell priming. Unexpectedly, we found that DC rapidly die by apoptosis once they have entered the T cell zone. Injection of OVA peptide in OVA-specific, TCR-transgenic mice strongly delays the LPS-induced apoptosis of DC in situ. We conclude that mature DC are programmed to die unless they receive a survival signal from T cells and that the regulation of DC survival may be a mechanism aimed at controlling the initiation and the termination of the immune response.
DOI：
10.1073/pnas.89.14.6550
发表时间：
1992-07-15
影响因子：
11.1
作者：
NOELLE, RJ;ROY, M;ARUFFO, A
通讯作者：
ARUFFO, A