Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons.
Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons.
复制标题
束和丝间基质显示适应能量存储肌腱疲劳性的适应性。
DOI：
10.1016/j.actbio.2016.06.012
复制
发表时间：
2016-09-15
影响因子：
9.7
通讯作者：
Screen, Hazel R. C.
中科院分区：
文献类型：
--
作者：
Thorpe, Chavaunne T.;Riley, Graham P.;Birch, Helen L.;Clegg, Peter D.;Screen, Hazel R. C.
肌腱由绳状束组成，束间基质（IFM）将其结合在一起。我们以前的工作表明，IFM是肌腱功能的关键，促进筋膜之间的滑动，让肌腱拉伸。这种功能在能量储存肌腱中特别重要，能量储存肌腱在运动期间经历极高的应变，因此需要相当大的束间滑动和反冲的能力。定位钢筋束不需要这种能力。虽然我们之前已经描述了IFM的准静态特性，但IFM在功能不同的肌腱中的抗疲劳性仍然未知。因此，我们测试了这一假设，即在能量储存马浅趾屈肌腱（SDFT）的束和IFM更耐疲劳比那些在位置共同的指伸肌肌腱（CDET）。对两种肌腱类型的束和IFM进行循环疲劳试验，直至失效，并计算力学性能。结果表明，无论是fascicles和IFM从能量存储SDFT能够抵抗更多的次数比那些从位置CDET之前的失败。此外，SDFT纤维束和IFM在测试过程中表现出比CDET中的对应物更少的滞后。这是第一项评估IFM抗疲劳性的研究，证明IFM在肌腱内具有功能性作用，并对肌腱力学性能有显着贡献。这些数据为充分表征肌腱结构-功能关系提供了重要进展。了解肌腱-结构-功能关系对于制定有效的预防措施和治疗肌腱损伤至关重要。在这项研究中，我们首次证明了束间基质能够承受高度的循环载荷，并专门用于改善储能肌腱的抗疲劳性。这些发现突出了束间基质在肌腱储能功能中的重要性，并可能为开发专门针对束间基质的肌腱损伤治疗方法提供新的途径。
Tendon is composed of rope-like fascicles, bound together by interfascicular matrix (IFM). Our previous work shows that the IFM is critical for tendon function, facilitating sliding between fascicles to allow tendons to stretch. This function is particularly important in energy storing tendons, which experience extremely high strains during exercise, and therefore require the capacity for considerable inter-fascicular sliding and recoil. This capacity is not required in positional tendons. Whilst we have previously described the quasi-static properties of the IFM, the fatigue resistance of the IFM in functionally distinct tendons remains unknown. We therefore tested the hypothesis that fascicles and IFM in the energy storing equine superficial digital flexor tendon (SDFT) are more fatigue resistant than those in the positional common digital extensor tendon (CDET). Fascicles and IFM from both tendon types were subjected to cyclic fatigue testing until failure, and mechanical properties were calculated. The results demonstrated that both fascicles and IFM from the energy storing SDFT were able to resist a greater number of cycles before failure than those from the positional CDET. Further, SDFT fascicles and IFM exhibited less hysteresis over the course of testing than their counterparts in the CDET. This is the first study to assess the fatigue resistance of the IFM, demonstrating that IFM has a functional role within tendon and contributes significantly to tendon mechanical properties. These data provide important advances into fully characterising tendon structure-function relationships. Understanding tendon-structure function relationships is crucial for the development of effective preventative measures and treatments for tendon injury. In this study, we demonstrate for the first time that the interfascicular matrix is able to withstand a high degree of cyclic loading, and is specialised for improved fatigue resistance in energy storing tendons. These findings highlight the importance of the interfascicular matrix in the function of energy storing tendons, and potentially provide new avenues for the development of treatments for tendon injury which specifically target the interfascicular matrix.
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DOI：
10.1002/jor.20722
发表时间：
2009-02
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Fung DT;Wang VM;Laudier DM;Shine JH;Basta-Pljakic J;Jepsen KJ;Schaffler MB;Flatow EL
通讯作者：
Flatow EL
影响因子：
9.7
作者：
Thorpe, Chavaunne T.;Klemt, Christian;Screen, Hazel R. C.
通讯作者：
Screen, Hazel R. C.
DOI：
10.1111/j.1365-2613.2007.00552.x
发表时间：
2007-08-07
影响因子：
3
作者：
Birch, Helen L.
通讯作者：
Birch, Helen L.
影响因子：
6
作者：
Ker, Robert F.
通讯作者：
Ker, Robert F.
影响因子：
2.9
作者：
KASTELIC, J;GALESKI, A;BAER, E
通讯作者：
BAER, E