A novel Sporothrix brasiliensis genomic variant in Midwestern Brazil: evidence for an older and wider sporotrichosis epidemic.
A novel Sporothrix brasiliensis genomic variant in Midwestern Brazil: evidence for an older and wider sporotrichosis epidemic.
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DOI：
10.1080/22221751.2020.1847001
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发表时间：
2020-12
影响因子：
13.2
通讯作者：
Nicola AM
中科院分区：
文献类型：
--
作者：
Eudes Filho J;Santos IBD;Reis CMS;Patané JSL;Paredes V;Bernardes JPRA;Poggiani SDSC;Castro TCB;Gomez OM;Pereira SA;Schubach EYP;Gomes KP;Mavengere H;Alves LGB;Lucas J;Paes HC;Albuquerque P;Cruz LM;McEwen JG;Stajich JE;Almeida-Paes R;Zancopé-Oliveira RM;Matute DR;Barker BM;Felipe MSS;Teixeira MM;Nicola AM
孢子丝菌病是一种由孢子丝菌属真菌引起的皮下感染。它通过接种在植物污染的材料或患病动物中发现的感染性颗粒传播，分别表征经典的sapronotic和新兴的人畜共患病传播。自1998年以来，巴西东南部发生了由沙门氏菌引起的人畜共患孢子虫病疫情。巴西，集中在里约热内卢州。我们在距离里约热内卢约900公里的布拉西利亚（巴西中西部）观察到猫孢子虫病病例，这使我们怀疑由S. 巴西脑炎从里约热内卢的震中传播，在两个地点独立出现，或者如果该疾病在巴西中西部存在且未被识别。对1993年至2018年期间来自布拉西利亚的91例人类和4例动物病例进行的回顾性分析表明，发生了sapronotic和人畜共患病传播。钙调素基因座的分子分型鉴定S。Schenckii作为代理在两个动物和所有七个人类患者，我们能够恢复临床分离。在另外两只动物中，该疾病是由S.巴西的。7种孢子丝菌的全基因组序列分型。来自布拉西利亚和里约热内卢的S.从布拉西利亚分离的巴西分离株与在里约热内卢暴发中心获得的分离株在基因组学和群体基因组学分析中均存在遗传差异。两个S。brasiliensis种群似乎在220万至310万年前分离，表明独立爆发或人畜共患病的S。巴西脑炎爆发可能比以前认识到的更早开始，在南美洲更广泛。
Sporotrichosis is a subcutaneous infection caused by fungi from the genus Sporothrix. It is transmitted by inoculation of infective particles found in plant-contaminated material or diseased animals, characterizing the classic sapronotic and emerging zoonotic transmission, respectively. Since 1998, southeastern Brazil has experienced a zoonotic sporotrichosis epidemic caused by S. brasiliensis, centred in the state of Rio de Janeiro. Our observation of feline sporotrichosis cases in Brasília (Midwestern Brazil), around 900 km away from Rio de Janeiro, led us to question whether the epidemic caused by S. brasiliensis has spread from the epicentre in Rio de Janeiro, emerged independently in the two locations, or if the disease has been present and unrecognized in Midwestern Brazil. A retrospective analysis of 91 human and 4 animal cases from Brasília, ranging from 1993 to 2018, suggests the occurrence of both sapronotic and zoonotic transmission. Molecular typing of the calmodulin locus identified S. schenckii as the agent in two animals and all seven human patients from which we were able to recover clinical isolates. In two other animals, the disease was caused by S. brasiliensis. Whole-genome sequence typing of seven Sporothrix spp. strains from Brasília and Rio de Janeiro suggests that S. brasiliensis isolates from Brasília are genetically distinct from those obtained at the epicentre of the outbreak in Rio de Janeiro, both in phylogenomic and population genomic analyses. The two S. brasiliensis populations seem to have separated between 2.2 and 3.1 million years ago, indicating independent outbreaks or that the zoonotic S. brasiliensis outbreak might have started earlier and be more widespread in South America than previously recognized.
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影响因子：
10.7
作者：
Minh BQ;Nguyen MA;von Haeseler A
通讯作者：
von Haeseler A
影响因子：
2.7
作者：
Cabanettes F;Klopp C
通讯作者：
Klopp C
影响因子：
3.8
作者：
Della Terra, Paula Portella;Rodrigues, Anderson Messias;de Camargo, Zoilo Pires
通讯作者：
de Camargo, Zoilo Pires
使用下一代 DNA 测序数据进行变异发现和基因分型的框架。
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
2.9
作者：
Almeida-Paes, Rodrigo;Evangelista Oliveira, Manoel Marques;Zancope-Oliveira, Rosely Maria
通讯作者：
Zancope-Oliveira, Rosely Maria