Management of itch in atopic dermatitis.
Management of itch in atopic dermatitis.
复制标题
DOI：
10.1016/j.sder.2011.05.002
复制
发表时间：
2011-06
影响因子：
--
通讯作者：
Steinhoff, Martin
中科院分区：
文献类型：
--
作者：
Hong, Judith;Buddenkotte, Joerg;Berger, Timothy G.;Steinhoff, Martin
特应性皮炎是一种常见的皮炎性炎症性皮肤病。慢性、局限性甚至全身性瘙痒是特应性皮炎的诊断标志，其治疗仍然是医生的一个挑战。在这些患者中，瘙痒和感觉异常的阈值明显降低，感染可促进病情加重，从而增加瘙痒。现代管理包括抗炎，偶尔防腐，以及抗炎症治疗，以解决表皮屏障以及免疫调节或感染。轻度特应性皮炎可以通过局部治疗来控制，但中度至重度特应性皮炎通常需要联合全身治疗，包括抗过敏药物和免疫抑制药物、光疗和局部化合物。此外，患者教育和治疗方案，以帮助患者科普瘙痒和湿疹是优化长期管理的重要辅助策略。本文综述了各种局部、全身、补充和替代疗法，并为特应性皮炎瘙痒的长期优化控制提供了治疗阶梯。
Atopic dermatitis is a common, pruritic, inflammatory skin disorder. Chronic, localized, or even generalized pruritus is the diagnostic hallmark of atopic dermatitis, and its management remains a challenge for physicians. The threshold for itch and alloknesis is markedly reduced in these patients, and infections can promote exacerbation and thereby increase the itch. Modern management consists of anti-inflammatory, occasionally antiseptic, as well as antipruritic therapies to address the epidermal barrier as well as immunomodulation or infection. Mild forms of atopic dermatitis may be controlled with topical therapies, but moderate-to-severe forms often require a combination of systemic treatments consisting of antipruritic and immunosuppressive drugs, phototherapy, and topical compounds. In addition, patient education and a therapeutic regimen to help the patient cope with the itch and eczema are important adjuvant strategies for optimized long-term management. This review highlights various topical, systemic, and complementary and alternative therapies, as well as provide a therapeutic ladder for optimized long-term control of itch in atopic dermatitis.
登录
查看更多内容
影响因子：
6.5
作者：
Bigliardi, PL;Mei, BQ;Rufli, T
通讯作者：
Rufli, T
影响因子：
13.8
作者：
Bigliardi, Paul L.;Stammer, Holger;Bigliardi-Qi, Mei
通讯作者：
Bigliardi-Qi, Mei
影响因子：
10.3
作者：
Berth-Jones, J;Takwale, A;Graham-Brown, RAC
通讯作者：
Graham-Brown, RAC
影响因子：
3.6
作者：
Berberian, BJ;Breneman, DL;Bernstein, JE
通讯作者：
Bernstein, JE
DOI：
10.1007/bf01972748
发表时间：
1993-01-01
期刊：
AGENTS AND ACTIONS
影响因子：
--
作者：
ALOE, L;LEON, A;LEVIMONTALCINI, R
通讯作者：
LEVIMONTALCINI, R