Short exposure to an enriched environment accelerates plasticity in the barrel cortex of adult rats.
Short exposure to an enriched environment accelerates plasticity in the barrel cortex of adult rats.
复制标题
DOI：
10.1016/j.neuroscience.2006.02.043
复制
发表时间：
2006-06-30
期刊：
影响因子：
3.3
通讯作者：
Ebner, F. F.
中科院分区：
文献类型：
--
作者：
Rema, V.;Armstrong-James, M.;Jenkinson, N.;Ebner, F. F.
关键词：
皮层感觉神经元调整其反应特性，以使用和停用其感受野中的外周受体。突触强度的变化可以通过简单地改变输入活动的平衡而在皮层中产生，因此活动水平的持续偏差改变了皮层感受野特性。这种依赖于活动的可塑性皮质细胞反应发生在大鼠皮质时，所有但两个胡须修剪了一段时间，在任何年龄。在24小时内首次在颗粒上层中观察到对完整胡须的诱发反应的上调[体感皮层可塑性的分层比较。Science 265（5180）：1885-1888]，并持续直到达到新的稳定状态[成年大鼠桶状皮质中的经验依赖性可塑性。Proc Natl Acad Sci U S A 90（5）：2082-2086; Armstrong-James M，Diamond ME，Ebner FF（1994）成年大鼠中使用胡须的无害偏差改变了桶皮质神经元的感受野。J Neurosci 14：6978-6991]。这些和许多其他的结果表明，皮层细胞反应的活动依赖性变化有一个积累阈值，可以更快地通过增加从感受野的活动区域产生的尖峰率来实现。在这里，我们测试的假设，即神经元反应的变化率可以通过将动物放置在高活动环境中胡须修剪后加速。测试刺激揭示了一个高度显着的感受野偏见在响应完整和修剪胡须在第四层以及在第二-III层的神经元，在只有15小时后，胡须修剪。第四层桶细胞未能显示可塑性后，15-24小时，在一个标准的笼子里的环境，但产生的响应偏差时，活动是由丰富的环境升高。我们的结论是，升高的活动更快地达到反应修改的阈值，这反过来又加快了感受野可塑性的速度。
Cortical sensory neurons adapt their response properties to use and disuse of peripheral receptors in their receptive field. Changes in synaptic strength can be generated in cortex by simply altering the balance of input activity, so that a persistent bias in activity levels modifies cortical receptive field properties. Such activity-dependent plasticity in cortical cell responses occurs in rat cortex when all but two whiskers are trimmed for a period of time at any age. The up-regulation of evoked responses to the intact whiskers is first seen within 24 h in the supragranular layers [ Laminar comparison of somatosensory cortical plasticity. Science 265(5180):1885–1888] and continues until a new stable state is achieved [ Experience-dependent plasticity in adult rat barrel cortex. Proc Natl Acad Sci U S A 90(5):2082–2086; Armstrong-James M, Diamond ME, Ebner FF (1994) An innocuous bias in whisker use in adult rat modifies receptive fields of barrel cortex neurons. J Neurosci 14:6978–6991]. These and many other results suggest that activity-dependent changes in cortical cell responses have an accumulation threshold that can be achieved more quickly by increasing the spike rate arising from the active region of the receptive field. Here we test the hypothesis that the rate of neuronal response change can be accelerated by placing the animals in a high activity environment after whisker trimming. Test stimuli reveal an highly significant receptive field bias in response to intact and trimmed whiskers in layer IV as well as in layers II–III neurons in only 15 h after whisker trimming. Layer IV barrel cells fail to show plasticity after 15–24 h in a standard cage environment, but produce a response bias when activity is elevated by the enriched environment. We conclude that elevated activity achieves the threshold for response modification more quickly, and this, in turn, accelerates the rate of receptive field plasticity.
登录
查看更多内容
DOI：
10.1073/pnas.89.10.4363
发表时间：
1992-05-15
影响因子：
11.1
作者：
DUDEK, SM;BEAR, MF
通讯作者：
BEAR, MF
影响因子：
0.9
作者：
CALFORD, MB;TWEEDALE, R
通讯作者：
TWEEDALE, R
影响因子：
2.5
作者：
ARMSTRONGJAMES, M;FOX, K
通讯作者：
FOX, K
影响因子：
16.2
作者：
Feldman, DE
通讯作者：
Feldman, DE
影响因子：
2.5
作者：
CALFORD, MB;TWEEDALE, R
通讯作者：
TWEEDALE, R