Monitoring of response to radiotherapy with fluorine-18 deoxyglucose PET of head and neck squamous cell carcinomas.
Monitoring of response to radiotherapy with fluorine-18 deoxyglucose PET of head and neck squamous cell carcinomas.
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头颈鳞状细胞癌氟 18 脱氧葡萄糖 PET 放射治疗反应监测。
DOI：
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
H. Ochi
中科院分区：
文献类型：
--
作者：
H. Sakamoto;Y. Nakai;Y. Ohashi;M. Matsuda;Tetushi Sakashita;Y. Nasako;Hayato Kitayama;J. Kawabe;T. Okamura;H. Ochi
我们用18F脱氧葡萄糖(FDG)进行正电子发射断层扫描(PET)，以确定放疗和化疗对头颈部恶性肿瘤的疗效。对22例头颈部病变患者进行了组织学检查。所有病例均经组织学确诊为鳞状细胞癌。其中16例在卡铂治疗的基础上接受了约40Gy射线的放射治疗。其余6例单纯放射治疗。在这些治疗后，11人接受了手术。对于PET研究，每个患者都静脉注射FDG185-370MBq。我们使用注射后40-55分钟的扫描图像来评估FDG的积聚程度。我们测量了标准化摄取值(SUV)，这是一种半定量的评估，ROI活动除以每个患者的每体重剂量。每例患者在治疗前后分别进行2次FDG-PET、CT和MRI检查。治疗后，每个患者的FDG摄取显著减少，但CT或MRI显示的肿瘤大小并不明显。因此，我们的研究结果清楚地表明，FDG-PET比CT和MRI等常规成像提供了更有价值的治疗结果。因此，FDG-PET应该为头颈部恶性肿瘤的治疗提供一个新的维度。
We examined the usefulness of positron emission tomography (PET) using fluorine-18 deoxyglucose (FDG) in determining the therapeutic effects of irradiation and chemotherapy on head and neck malignant tumors. Twenty-two patients with head and neck lesions who underwent histological examinations were studied. Squamous cell carcinoma was histologically diagnosed in all cases. Sixteen of them underwent radiotherapy with approximately 40 Gy in combination with carboplatin therapy. The remaining 6 patients underwent radiotherapy alone. After these treatments, 11 underwent surgery. For PET study, each patient was injected with intravenous FDG 185-370 MBq. We evaluated the degree of FDG accumulation using scanned images taken 40-55 min after the injection. We measured the standardized uptake value (SUV), a semiquantative evaluation, ROI activity divided by the dosage per weight of each patient. FDG-PET, CT and MRI were performed twice for each patient, before and after treatment. FDG uptake, but not the tumor size in CT or MRI, was significantly reduced in each patient after the treatment. Therefore, our findings have clearly demonstrated that FDG-PET provides for more valuable therapeutic outcomes than conventional imaging such as CT and MRI. FDG-PET should thus provide a new dimension in the management of head and neck malignant tumors.
DOI：
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发表时间：
1991-04
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
L. Strauss;P. Conti
通讯作者：
L. Strauss;P. Conti
影响因子：
19.7
作者：
JABOUR, BA;CHOI, Y;ABEMEYOR, E
通讯作者：
ABEMEYOR, E