The role of the aryl hydrocarbon receptor in the female reproductive system.
The role of the aryl hydrocarbon receptor in the female reproductive system.
复制标题
芳基烃受体在女性生殖系统中的作用。
DOI：
10.1016/j.bcp.2008.09.037
复制
发表时间：
2009-02-15
影响因子：
5.8
通讯作者：
Flaws, Jodi A.
中科院分区：
文献类型：
--
作者：
Hernandez-Ochoa, Isabel;Karman, Bethany N.;Flaws, Jodi A.
近年来，许多研究强调了芳香烃受体（AHR）介导的基因表达的变化如何导致生物学效应，引起了人们对该受体作为正常生物学功能调节剂的兴趣。本文综述了AHR在女性生殖系统（包括卵巢、输卵管或输卵管、子宫和阴道）中的作用。这篇综述还重点介绍了AHR在生殖结局中的作用，如周期性、衰老和生育力。具体而言，使用有效的AHR配体，以及缺乏AHR信号通路的转基因小鼠的研究进行了讨论，从了解这种配体激活的转录因子在女性生殖寿命的内源性作用的观点。基于本文强调的研究结果，提出AHR具有生理功能，包括卵巢功能，建立最佳受精环境，滋养胚胎和维持妊娠，以及调节生殖寿命和生育力。AHR调节女性生殖的机制知之甚少，但预计新的模型和产生特定基因缺失的能力将为更好地了解AHR途径的改变如何导致女性生殖系统的功能变化提供强大的实验工具。
In recent years, many studies have emphasized how changes in aryl hydrocarbon receptor (AHR)-mediated gene expression result in biological effects, raising interest in this receptor as a regulator of normal biological function. This review focuses on what is known about the role of the AHR in the female reproductive system, which includes the ovaries, fallopian tubes or oviduct, uterus and vagina. This review also focuses on the role of the AHR in reproductive outcomes such as cyclicity, senescence, and fertility. Specifically, studies using potent AHR ligands, as well as transgenic mice lacking the AHR signaling pathway are discussed from a viewpoint of understanding the endogenous role of this ligand-activated transcription factor in the female reproductive lifespan. Based on findings highlighted in this paper, it is proposed that the AHR has a role in physiological functions including ovarian function, establishment of an optimum environment for fertilization, nourishing the embryo and maintaining pregnancy, as well as in regulating reproductive lifespan and fertility. The mechanisms by which the AHR regulates female reproduction are poorly understood, but it is anticipated that new models and the ability to generate specific gene deletions will provide powerful experimental tools for better understanding how alterations in AHR pathways result in functional changes in the female reproductive system.
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影响因子：
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