Flavivirus-host interactions: an expanding network of proviral and antiviral factors.

Flavivirus-host interactions: an expanding network of proviral and antiviral factors.
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黄病毒-宿主相互作用:前病毒和抗病毒因子的扩大网络。

DOI:
10.1016/j.coviro.2021.11.007
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发表时间:
2022-03
影响因子:
5.9
通讯作者:
Hoffmann HH
Hoffmann HH
中科院分区:
医学2区
文献类型:
--
作者:
Schneider WM;Hoffmann HH

文献摘要

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黄病毒是由受感染的蚊子和蜱虫叮咬传播的人畜共患病原体,对人类健康构成了持续的负担。在这里,我们回顾了最近的文献,旨在揭示黄病毒如何与它们感染的细胞相互作用。更好地了解这些相互作用可能最终导致新的治疗靶点。我们重点介绍了几项采用低偏倚方法发现新的蛋白质-蛋白质、蛋白质- rna和遗传相互作用的研究,并重点介绍了最近表征宿主蛋白TMEM41B的工作,该蛋白已被证明对多种黄病毒和冠状病毒的感染至关重要。
Flaviviruses are zoonotic pathogens transmitted by the bite of infected mosquitos and ticks and represent a constant burden to human health. Here we review recent literature aimed at uncovering how flaviviruses interact with the cells that they infect. A better understanding of these interactions may ultimately lead to novel therapeutic targets. We highlight several studies that employed low-biased methods to discover new protein–protein, protein–RNA, and genetic interactions, and spotlight recent work characterizing the host protein, TMEM41B, which has been shown to be critical for infection by diverse flaviviruses and coronaviruses.
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