Obesity Increases the Severity and Mortality of Influenza and COVID-19: A Systematic Review and Meta-Analysis.
Obesity Increases the Severity and Mortality of Influenza and COVID-19: A Systematic Review and Meta-Analysis.
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肥胖会增加流感和 COVID-19 的严重程度和死亡率：系统回顾和荟萃分析
DOI：
10.3389/fendo.2020.595109
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发表时间：
2020
影响因子：
5.2
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Zhao X;Gang X;He G;Li Z;Lv Y;Han Q;Wang G
2019年12月以来，COVID-19引起全球关注。研究表明肥胖与流感和COVID-19的严重后果之间存在联系。因此，我们旨在通过进行荟萃分析，比较肥胖对流感和COVID-19的严重程度和死亡率的影响。从2009年1月至2020年7月，在MEDLINE、EMASE、ClinicalTrials.gov和Web of Science中进行了系统检索。该方案已在PROSPERO（CRD 42020201461）上注册。经过筛选，46项研究被纳入本荟萃分析。分析合并比值比（OR）和95%置信区间（CI）。我们发现肥胖是流感严重程度和死亡率的危险因素（OR严重结局= 1.56，CI：1.28-1.90; OR死亡率= 1.99，CI：1.15-3.46）。对于COVID-19，肥胖仅是严重结局的显著风险因素（OR = 2.07，CI：1.53-2.81），但不是死亡率的显著风险因素（OR = 1.57，CI：0.85-2.90）。与肥胖相比，病态肥胖与流感（OR = 1.40，CI：1.10-1.79）和COVID-19（OR = 3.76，CI：2.67-5.28）的严重程度和死亡率的风险更高有关。因此，应建议将肥胖作为COVID-19预后评估的风险因素。对肥胖和COVID-19患者应实施特殊监测和早期治疗。
Since December 2019, COVID-19 has aroused global attention. Studies show the link between obesity and severe outcome of influenza and COVID-19. Thus, we aimed to compare the impacts of obesity on the severity and mortality of influenza and COVID-19 by performing a meta-analysis. A systematic search was performed in MEDLINE, EMASE, ClinicalTrials.gov, and Web of Science from January 2009 to July 2020. The protocol was registered onto PROSPERO (CRD42020201461). After selection, 46 studies were included in this meta-analysis. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were analyzed. We found obesity was a risk factor for the severity and mortality of influenza (ORsevere outcome = 1.56, CI: 1.28-1.90; ORmortality = 1.99, CI: 1.15-3.46). For COVID-19, obesity was a significant risk factor only for severe outcome (OR = 2.07, CI: 1.53-2.81) but not for mortality (OR = 1.57, CI: 0.85-2.90). Compared with obesity, morbid obesity was linked with a higher risk for the severity and mortality of both influenza (OR = 1.40, CI: 1.10-1.79) and COVID-19 (OR = 3.76, CI: 2.67-5.28). Thus, obesity should be recommended as a risk factor for the prognosis assessment of COVID-19. Special monitoring and earlier treatment should be implemented in patients with obesity and COVID-19.
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评估肥胖症是医学上参加实验室确认的流感的独立危险因素。
影响因子：
4.4
作者：
Coleman LA;Waring SC;Irving SA;Vandermause M;Shay DK;Belongia EA
通讯作者：
Belongia EA
肥胖症的社区流行与相关行为因素与与流感相关住院的社区率之间的关系。
影响因子：
4.4
作者：
Charland KM;Buckeridge DL;Hoen AG;Berry JG;Elixhauser A;Melton F;Brownstein JS
通讯作者：
Brownstein JS
影响因子：
4
作者：
Lo CK;Mertz D;Loeb M
通讯作者：
Loeb M
影响因子：
9.6
作者：
Diaz, Emili;Rodriguez, Alejandro;Rello, Jordi
通讯作者：
Rello, Jordi
影响因子：
4.5
作者：
Guerrisi, Caroline;Ecollan, Marie;Blanchon, Thierry
通讯作者：
Blanchon, Thierry