Evaluation of obesity as an independent risk factor for medically attended laboratory-confirmed influenza.
Evaluation of obesity as an independent risk factor for medically attended laboratory-confirmed influenza.
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评估肥胖症是医学上参加实验室确认的流感的独立危险因素。
DOI：
10.1111/j.1750-2659.2012.00377.x
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发表时间：
2013-03
影响因子：
4.4
通讯作者：
Belongia EA
中科院分区：
文献类型：
--
作者：
Coleman LA;Waring SC;Irving SA;Vandermause M;Shay DK;Belongia EA
请引用这篇论文：科尔曼等人。（2013）肥胖作为医学参与的实验室确诊流感的独立风险因素的评估。流感和其他呼吸道病毒7（2）160-167。 背景肥胖与人类流感感染易感性之间的关系尚不清楚。 2009年甲型H1N1流感大流行[A（H1N1）pdm 09]导致病态肥胖人群并发症的风险增加。 目的本研究的目的是确定在患有急性呼吸道疾病的成人中，经医学观察、实验室确认的流感是否与肥胖独立相关。 患者/方法从2007-2008年（n = 903）、2008-2009年（n = 869）和2009年大流行季节（n = 851）的人群队列中招募因急性呼吸道疾病就诊的≥20岁成人。 通过真实的实时逆转录聚合酶链反应检测鼻咽拭子中的流感病毒。使用电子病历中的数据计算体重指数（BMI）。Logistic回归评估了流感与肥胖之间的关联，调整了性别，疫苗接种，年龄和高风险医疗条件。 结果：2007-2008年，50%的患者检出流感，2008-2009年为15%，2009年大流行期间为14%。 2007-2008年，该人群中的主要季节性病毒为甲型H3 N2，2008-2009年为甲型H1 N1和B。在所有季节，流感患者的平均（±SD）BMI为30·58（±7·31），试验阴性对照组为30·93（±7·55）。流感患者的平均BMI不随季节变化。在调整混杂因素后，肥胖和极度肥胖与流感的季节或所有年份的合并均无关（肥胖和极度肥胖的OR分别为0.95：95%CI 0.75，1.20和1.10：0.80，1.52，所有年份）。 结论：在该人群中，肥胖与患有急性呼吸道疾病的成年人中的流感相关。
Please cite this paper as: Coleman et al. (2013) Evaluation of obesity as an independent risk factor for medically attended laboratory‐confirmed influenza. Influenza and Other Respiratory Viruses 7(2) 160–167. Background The relationship between obesity and susceptibility to influenza infection in humans is unclear. Morbidly obese people were at an increased risk of complications from 2009 pandemic H1N1 influenza [A(H1N1)pdm09]. Objective The goal of this study was to determine whether medically attended, laboratory‐confirmed influenza is independently associated with obesity in adults with acute respiratory illness. Patients/Methods Adults ≥20 years with a medical encounter for acute respiratory illness were recruited from a population cohort during the 2007–2008 (n = 903), 2008–2009 (n = 869), and 2009 pandemic (n = 851) season. Nasopharyngeal swabs were tested for influenza by real‐time reverse‐transcription polymerase chain reaction. Body mass index (BMI) was calculated using data from the electronic medical record. Logistic regression evaluated the association between influenza and obesity, adjusting for gender, vaccination, age, and high‐risk medical condition. Results Influenza was detected in 50% of patients in 2007–2008, 15% in 2008–2009, and 14% during the 2009 pandemic. Predominant seasonal viruses in this population were A/H3N2 in 2007–2008, and A/H1N1 and B in 2008–2009. Mean (±SD) BMI was 30·58 (±7·31) in patients with influenza and 30·93 (±7·55) in test‐negative controls during all seasons. Mean BMI of patients with influenza did not vary by season. After adjusting for confounders, neither obesity nor extreme obesity were associated with influenza by season or for all years combined (OR 0·95: 95% CI 0·75, 1·20 and 1·10: 0·80, 1·52, respectively, for obesity and extreme obesity, all years). Conclusions Obesity was not associated with medically attended influenza among adults with acute respiratory illness in this population.
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