Treatment and Prevention of Depression and Anxiety in Youth: Test of Cross-Over Effects.
Treatment and Prevention of Depression and Anxiety in Youth: Test of Cross-Over Effects.
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DOI：
10.1002/da.22519
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发表时间：
2016-10
影响因子：
7.4
通讯作者：
Weersing, V. Robin
中科院分区：
文献类型：
--
作者：
Garber, Judy;Brunwasser, Steven M.;Zerr, Argero A.;Schwartz, Karen T. G.;Sova, Karen;Weersing, V. Robin
焦虑和抑郁是高度共病的，并有几个共同的病因过程。因此，制定干预措施，共同治疗或预防这些问题，而不是作为单独的实体，可能会更有效。本荟萃分析综述检查了明确针对焦虑或抑郁的儿童和青少年干预措施是否显示出治疗特异性或也影响其他结局（即，交叉效应）。我们在同一类型的研究中解决了这个问题（即，治疗、预防）和跨研究类型。只有随机对照试验（RCT），评估两个结构的尺寸措施被纳入本审查。对于治疗研究，针对焦虑的随机对照试验（n=18）显示对焦虑和抑郁症状均有显著影响，但对焦虑的影响大于抑郁;同样，治疗抑郁的随机对照试验（n=9）对抑郁和焦虑症状均有显著影响，但对抑郁的影响大于焦虑。因此，据称针对焦虑或抑郁的治疗存在交叉效应，而且还有治疗特异性，因此对于治疗所针对的目标问题可以看到更大的效果。焦虑预防研究（n=14）显着影响焦虑，但不抑郁症状，表明没有交叉效应的焦虑预防试验抑郁症。对于抑郁症预防研究（n=15），无论是抑郁症或焦虑症状的影响是不显着的，虽然效果是显着大于抑郁症的焦虑症状。事后分析显示，对抑郁症状的影响是显着的抑郁症预防试验的目标，但不是普遍的样本。跨诊断干预的影响进行了讨论。
Anxiety and depression are highly comorbid and share several common etiological processes. Therefore, it may be more efficient to develop interventions that treat or prevent these problems together rather than as separate entities. The present meta-analytic review examined whether interventions for children and adolescents that explicitly targeted either anxiety or depression showed treatment specificity or also impacted the other outcome (i.e., cross-over effects). We addressed this question both within the same type of study (i.e., treatment, prevention) and across study types. Only randomized controlled trials (RCTs) that assessed both constructs with dimensional measures were included in this review. For treatment studies, RCTs targeting anxiety (n=18) showed significant effects on both anxious and depressive symptoms, although more strongly on anxiety than depression; similarly, RCTs treating depression (n=9) yielded significant effects on both depressive and anxious symptoms, but stronger effects on depression than anxiety. Thus, there were cross-over effects in treatments purportedly targeting either anxiety or depression, and also treatment specificity, such that larger effects were seen for the target problem at which the treatment was aimed. Anxiety prevention studies (n=14) significantly affected anxious, but not depressive symptoms, indicating no cross-over effect of anxiety prevention trials on depression. For depression prevention studies (n=15), the effects were not significant for either depressive or anxiety symptoms, although the effect was significantly larger for depressive than for anxious symptoms. Post-hoc analyses revealed that the effect on depressive symptoms was significant in depression preventions trials of targeted but not universal samples. Implications for transdiagnostic interventions are discussed.
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影响因子：
22.4
作者：
Cummings, Colleen M.;Caporino, Nicole E.;Kendall, Philip C.
通讯作者：
Kendall, Philip C.
影响因子：
1.7
作者：
Beesdo, Katja;Knappe, Susanne;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
5.9
作者：
Barrett, PM;Dadds, MR;Rapee, RM
通讯作者：
Rapee, RM
DOI：
10.1080/1754730x.2012.730352
发表时间：
2012-01-01
期刊：
ADVANCES IN SCHOOL MENTAL HEALTH PROMOTION
影响因子：
--
作者：
Ahlen, Johan;Breitholtz, Elisabeth;Gallegos, Julia
通讯作者：
Gallegos, Julia
影响因子：
2.7
作者：
Day, C;Kane, RT;Roberts, C
通讯作者：
Roberts, C