Association of decreased serum brain-derived neurotrophic factor (BDNF) concentrations in early pregnancy with antepartum depression.
Association of decreased serum brain-derived neurotrophic factor (BDNF) concentrations in early pregnancy with antepartum depression.
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DOI：
10.1186/s12888-015-0428-7
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发表时间：
2015-03-10
期刊：
影响因子：
4.4
通讯作者：
Williams MA
中科院分区：
文献类型：
--
作者：
Fung J;Gelaye B;Zhong QY;Rondon MB;Sanchez SE;Barrios YV;Hevner K;Qiu C;Williams MA
产前抑郁是导致产妇在产前发病和死亡的主要原因之一。越来越多的证据表明脑源性神经营养因子（BDNF）在抑郁症病理生理中的作用。本研究探讨了孕妇妊娠早期血清BDNF水平与产前抑郁的关联程度。共有968名妇女在怀孕早期被招募和采访。采用患者健康问卷-9 （PHQ-9）量表评估产前抑郁患病率及症状严重程度。采用竞争性酶联免疫吸附试验（ELISA）测定母体血清BDNF水平。采用逻辑回归程序估计混杂因素校正后的优势比（OR）和95%置信区间（95% CI）。产前抑郁妇女妊娠早期血清BDNF水平明显低于无抑郁妇女（平均±标准差[SD]: 20.78±5.97比21.85±6.42 ng/ml, p = 0.024）。较低的BDNF水平与产妇产前抑郁的几率增加有关。在调整混杂因素后，血清BDNF水平处于最低三个四分位数（<17.32 ng/ml）的妇女与BDNF水平处于最高四分位数（25.31 ng/ml）的妇女相比，产前抑郁的几率增加了1.61倍（OR = 1.61, 95% CI: 1.13, 2.30）。没有证据表明BDNF水平与抑郁症状严重程度有关。妊娠早期产妇血清BDNF水平较低与产前抑郁有关。这些发现可能指向新的治疗机会，BDNF应被评估为产前抑郁症风险预测和治疗反应监测的潜在生物标志物。本文的在线版本（doi:10.1186/s12888-015-0428-7）包含补充材料，授权用户可以使用。
Antepartum depression is one of the leading causes of maternal morbidity and mortality in the prenatal period. There is accumulating evidence for the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression. The present study examines the extent to which maternal early pregnancy serum BDNF levels are associated with antepartum depression. A total of 968 women were recruited and interviewed in early pregnancy. Antepartum depression prevalence and symptom severity were assessed using the Patient Health Questionnaire-9 (PHQ-9) scale. Maternal serum BDNF levels were measured using a competitive enzyme-linked immunosorbent assay (ELISA). Logistic regression procedures were performed to estimate odds ratios (OR) and 95% confidence intervals (95% CI) adjusted for confounders. Maternal early pregnancy serum BDNF levels were significantly lower in women with antepartum depression compared to women without depression (mean ± standard deviation [SD]: 20.78 ± 5.97 vs. 21.85 ± 6.42 ng/ml, p = 0.024). Lower BDNF levels were associated with increased odds of maternal antepartum depression. After adjusting for confounding, women whose serum BDNF levels were in the lowest three quartiles (<17.32 ng/ml) had 1.61-fold increased odds (OR = 1.61, 95% CI: 1.13, 2.30) of antepartum depression as compared with women whose BDNF levels were in the highest quartile (>25.31 ng/ml). There was no evidence of an association of BDNF levels with depression symptom severity. Lower maternal serum BDNF levels in early pregnancy are associated with antepartum depression. These findings may point toward new therapeutic opportunities and BDNF should be assessed as a potential biomarker for risk prediction and monitoring response to treatment for antepartum depression. The online version of this article (doi:10.1186/s12888-015-0428-7) contains supplementary material, which is available to authorized users.
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影响因子：
2.1
作者：
Ghasemi A;Zahediasl S
通讯作者：
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影响因子：
3
作者：
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影响因子：
11.3
作者：
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3.7
作者：
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Gomez-Pinilla F
DOI：
10.1080/01674820600915478
发表时间：
2006-12-01
影响因子：
3.1
作者：
Adewuya, Abiodun O.;ola, B. A. Ola;Fasoto, Olubunmi O.
通讯作者：
Fasoto, Olubunmi O.