Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood.
Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood.
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DOI：
10.1371/journal.pone.0028451
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Gomez-Pinilla F
中科院分区：
文献类型：
--
作者：
Bhatia HS;Agrawal R;Sharma S;Huo YX;Ying Z;Gomez-Pinilla F
Omega-3-脂肪酸 DHA 是大脑质膜的结构成分，因此对神经信号传导至关重要；然而，大脑合成 DHA 的效率很低。我们询问大脑生长过程中饮食中的 n-3 脂肪酸水平如何影响成年后的大脑功能和可塑性。怀孕大鼠及其雄性后代被喂食 n-3 充足饮食或 n-3 缺乏饮食 15 周。结果表明，通过旷场和高架十字迷宫测试，n-3 缺乏症增加了雄性后代的焦虑样行为参数。行为改变伴随着认知相关额叶皮层、下丘脑和海马中与抗焦虑相关的神经肽Y-1受体水平降低，以及与焦虑相关的糖皮质激素受体增加。 n-3 缺乏症降低了大脑中二十二碳六烯酸 (DHA) 的水平，并增加了气相色谱法评估的 n-6/n-3 比率。 n-3 缺陷会降低 BDNF 的水平以及通过 BDNF 受体 TrkB 的信号传导（与大脑 DHA 水平成比例），并减少特定大脑区域 BDNF 相关信号传导分子 CREB 的激活。 n-3 缺乏还会破坏胰岛素信号传导途径，胰岛素受体 (IR) 和胰岛素受体底物 (IRS) 的变化就证明了这一点。大脑成熟过程中 DHA 缺乏会降低成年期的可塑性并损害大脑功能。膳食中充足的 DHA 似乎对于建立长期神经元恢复能力、实现最佳大脑功能和帮助对抗神经系统疾病至关重要。
Omega-3-fatty acid DHA is a structural component of brain plasma membranes, thereby crucial for neuronal signaling; however, the brain is inefficient at synthesizing DHA. We have asked how levels of dietary n-3 fatty acids during brain growth would affect brain function and plasticity during adult life. Pregnant rats and their male offspring were fed an n-3 adequate diet or n-3 deficient diets for 15 weeks. Results showed that the n-3 deficiency increased parameters of anxiety-like behavior using open field and elevated plus maze tests in the male offspring. Behavioral changes were accompanied by a level reduction in the anxiolytic-related neuropeptide Y-1 receptor, and an increase in the anxiogenic-related glucocorticoid receptor in the cognitive related frontal cortex, hypothalamus and hippocampus. The n-3 deficiency reduced brain levels of docosahexaenoic acid (DHA) and increased the ratio n-6/n-3 assessed by gas chromatography. The n-3 deficiency reduced the levels of BDNF and signaling through the BDNF receptor TrkB, in proportion to brain DHA levels, and reduced the activation of the BDNF-related signaling molecule CREB in selected brain regions. The n-3 deficiency also disrupted the insulin signaling pathways as evidenced by changes in insulin receptor (IR) and insulin receptor substrate (IRS). DHA deficiency during brain maturation reduces plasticity and compromises brain function in adulthood. Adequate levels of dietary DHA seem crucial for building long-term neuronal resilience for optimal brain performance and aiding in the battle against neurological disorders.
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影响因子：
3.2
作者：
Lépine JP;Briley M
通讯作者：
Briley M
影响因子：
3.3
作者：
Jacka, Felice N.;Mykletun, Arnstein;Tell, Grethe S.
通讯作者：
Tell, Grethe S.
影响因子：
10.6
作者：
Ernst, Carl;Wanner, Brigitte;Turecki, Gustavo
通讯作者：
Turecki, Gustavo
DOI：
10.1152/ajpregu.90585.2008
发表时间：
2009-10-01
影响因子：
2.8
作者：
Page, Kathleen C.;Malik, Raleigh E.;Anday, Endla K.
通讯作者：
Anday, Endla K.
影响因子：
6.5
作者：
Igarashi, Miki;DeMar, James C., Jr.;Rapoport, Stanley I.
通讯作者：
Rapoport, Stanley I.