A systematic summary of survival and death signalling during the life of hair follicle stem cells.
A systematic summary of survival and death signalling during the life of hair follicle stem cells.
复制标题
毛囊干细胞生命过程中生存和死亡信号的系统总结
DOI：
10.1186/s13287-021-02527-y
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发表时间：
2021-08-11
影响因子：
7.5
通讯作者：
Xiong K
中科院分区：
文献类型：
--
作者：
Hu XM;Li ZX;Zhang DY;Yang YC;Fu SA;Zhang ZQ;Yang RH;Xiong K
毛囊干细胞（HFSC）是最广泛可用的资源之一，也是最常被批准用于研究成体干细胞的模型系统。HFSC由于其自我更新和分化特性而特别有用。此外，毛囊的周期性生长由HFSC驱动。对于HFSC作为用于研究有助于HFSC鉴定的分子机制的有利系统的用途有很高的期望，并且可以应用于脱发治疗，例如毛囊的活化或再生，以及使用组织工程策略产生毛发。多种分子参与了关键调节HFSC命运的网络，例如毛囊生长和发育中的因子（Wnt途径、Sonic hedgehog途径、Notch途径和BMP途径），以及抑制凋亡线索（凋亡途径）。在这里，我们回顾了HFSC的生命周期，生物标志物和功能，总结了HFSC命运中涉及的信号通路，以促进更好地理解HFSC生态位中的病理生理变化。重要的是，我们强调了与脱发和其他皮肤和毛发疾病（包括脱发、皮肤癌、皮肤炎症和皮肤伤口愈合）治疗相关的治疗靶点的潜在机制。
Hair follicle stem cells (HFSCs) are among the most widely available resources and most frequently approved model systems used for studying adult stem cells. HFSCs are particularly useful because of their self-renewal and differentiation properties. Additionally, the cyclic growth of hair follicles is driven by HFSCs. There are high expectations for the use of HFSCs as favourable systems for studying the molecular mechanisms that contribute to HFSC identification and can be applied to hair loss therapy, such as the activation or regeneration of hair follicles, and to the generation of hair using a tissue-engineering strategy. A variety of molecules are involved in the networks that critically regulate the fate of HFSCs, such as factors in hair follicle growth and development (in the Wnt pathway, Sonic hedgehog pathway, Notch pathway, and BMP pathway), and that suppress apoptotic cues (the apoptosis pathway). Here, we review the life cycle, biomarkers and functions of HFSCs, concluding with a summary of the signalling pathways involved in HFSC fate for promoting better understanding of the pathophysiological changes in the HFSC niche. Importantly, we highlight the potential mechanisms underlying the therapeutic targets involved in pathways associated with the treatment of hair loss and other disorders of skin and hair, including alopecia, skin cancer, skin inflammation, and skin wound healing.
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影响因子：
23.9
作者：
Adam RC;Yang H;Ge Y;Lien WH;Wang P;Zhao Y;Polak L;Levorse J;Baksh SC;Zheng D;Fuchs E
通讯作者：
Fuchs E
影响因子：
64.8
作者：
Blanco, Sandra;Bandiera, Roberto;Popis, Martyna;Hussain, Shobbir;Lombard, Patrick;Aleksic, Jelena;Sajini, Abdulrahim;Tanna, Hinal;Cortes-Garrido, Rosana;Gkatza, Nikoletta;Dietmann, Sabine;Frye, Michaela
通讯作者：
Frye, Michaela
影响因子：
64.8
作者：
Biehs, Brian;Dijkgraaf, Gerrit J. P.;de Sauvage, Frederic J.
通讯作者：
de Sauvage, Frederic J.
影响因子：
1.5
作者：
Aran, Saeideh;Zahri, Saber;Abdolmaleki, Arash
通讯作者：
Abdolmaleki, Arash
自体活化富血小板血浆（AA-PRP）注射对脱发的影响：临床和组织形态学评估。
影响因子：
--
作者：
Cervelli V;Garcovich S;Bielli A;Cervelli G;Curcio BC;Scioli MG;Orlandi A;Gentile P
通讯作者：
Gentile P