The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation.
The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation.
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自体活化富血小板血浆（AA-PRP）注射对脱发的影响：临床和组织形态学评估。
DOI：
10.1155/2014/760709
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发表时间：
2014
影响因子：
--
通讯作者：
Gentile P
中科院分区：
文献类型：
--
作者：
Cervelli V;Garcovich S;Bielli A;Cervelli G;Curcio BC;Scioli MG;Orlandi A;Gentile P
研究AA-PRP注射液治疗模式性脱发的安全性和临床疗效。从少量血液中制备的AA-PRP注射到一半选定的模式脱发患者的头皮上。另一半则接受安慰剂治疗。每例患者接受3次治疗，间隔1个月。终点为毛发再生、通过皮肤镜检查测量的毛发营养不良、烧灼感或瘙痒感以及通过Ki-67评价测量的细胞增殖。在3个治疗周期结束时，与基线值相比，患者的平均毛发数量出现临床改善，目标区域平均增加18.0根毛发，总毛发密度平均增加27.7根（毛发数量/cm 2）。显微镜检查显示，与基线值相比，最后一次AA-PRP治疗后2周，表皮厚度和毛囊数量增加（P < 0.05）。我们还观察到与基线相比，治疗皮肤中表皮的Ki 67+角质形成细胞和毛囊隆突细胞增加，毛囊周围的小血管轻微增加（P < 0.05）。
To investigate the safety and clinical efficacy of AA-PRP injections for pattern hair loss. AA-PRP, prepared from a small volume of blood, was injected on half of the selected patients' scalps with pattern hair loss. The other half was treated with placebo. Three treatments were given for each patient, with intervals of 1 month. The endpoints were hair re-growth, hair dystrophy as measured by dermoscopy, burning or itching sensation, and cell proliferation as measured by Ki-67 evaluation. At the end of the 3 cycles of treatment, the patients presented clinical improvement in the mean number of hairs, with a mean increase of 18.0 hairs in the target area, and a mean increase in total hair density of 27.7 ( number of hairs/cm2) compared with baseline values. Microscopic evaluation showed the increase of epidermis thickness and of the number of hair follicles two weeks after the last AA-PRP treatment compared to baseline value (P < 0.05). We also observed an increase of Ki67+ keratinocytes of epidermis and of hair follicular bulge cells and a slight increase of small blood vessels around hair follicles in the treated skin compared to baseline (P < 0.05).
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影响因子：
6.5
作者：
Lachgar, S;Moukadiri, H;Plouet, J
通讯作者：
Plouet, J
影响因子：
1.2
作者：
Cervelli, Valerio;Gentile, Pietro;Orlandi, Augusto
通讯作者：
Orlandi, Augusto
影响因子：
3.6
作者：
Li, Weiwei;Enomoto, Mitsuhiro;Okawa, Atsushi
通讯作者：
Okawa, Atsushi
影响因子：
5.3
作者：
Ferlosio, Amedeo;Arcuri, Gaetano;Orlandi, Augusto
通讯作者：
Orlandi, Augusto
影响因子：
3
作者：
Kozlowska, U;Blume-Peytavi, U;Orfanos, CE
通讯作者：
Orfanos, CE