Cloned antigens and antiidiotypes.

Cloned antigens and antiidiotypes.
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克隆抗原和抗独特型。

DOI:
10.1089/hyb.1995.14.159
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发表时间:
1995
期刊:
Hybridoma.
影响因子:
--
通讯作者:
Sears,H
Sears,H
中科院分区:
--
文献类型:
--
作者:
Herlyn,D;Somasundaram,R;Zaloudik,J;Li,W;Jacob,L;Harris,D;Kieny,MP;Ricciardi,R;Gonczol,E;Sears,H

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Both monoclonal and polyclonal antiidiotypic antibodies mimicking the human colorectal carcinoma (CRC) associated antigen C017-1A/GA733 have induced antigen-specific humoral and cellular immunity in CRC patients. The immune responses may underlie the clinical responses observed in some of the treated patients. Recently, the C017-1A/GA733 antigen has been molecularly cloned and expressed in baculo-, adeno-, and vaccinia viruses. In preclinical studies, these recombinant antigen preparations elicited specific humoral immunity (cytotoxic antibodies) and cellular immunity (DTH-reactive and proliferative T cells). Antibody titers elicited in animals by recombinant antigen were significantly higher than those elicited by antiidiotypes. The recombinant antigen has a potential as a vaccine for CRC patients.
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DOI: --
发表时间: 1985
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影响因子: --
作者:
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影响因子: --
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作者:
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影响因子: 11.1
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影响因子: --
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Herlyn,D;Ross,AH;Koprowski,H
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