Cloned antigens and antiidiotypes.
Cloned antigens and antiidiotypes.
复制标题
克隆抗原和抗独特型。
DOI:
10.1089/hyb.1995.14.159
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发表时间:
1995
期刊:
影响因子:
--
通讯作者:
Sears,H
中科院分区:
文献类型:
--
作者:
Herlyn,D;Somasundaram,R;Zaloudik,J;Li,W;Jacob,L;Harris,D;Kieny,MP;Ricciardi,R;Gonczol,E;Sears,H
Both monoclonal and polyclonal antiidiotypic antibodies mimicking the human colorectal carcinoma (CRC) associated antigen C017-1A/GA733 have induced antigen-specific humoral and cellular immunity in CRC patients. The immune responses may underlie the clinical responses observed in some of the treated patients. Recently, the C017-1A/GA733 antigen has been molecularly cloned and expressed in baculo-, adeno-, and vaccinia viruses. In preclinical studies, these recombinant antigen preparations elicited specific humoral immunity (cytotoxic antibodies) and cellular immunity (DTH-reactive and proliferative T cells). Antibody titers elicited in animals by recombinant antigen were significantly higher than those elicited by antiidiotypes. The recombinant antigen has a potential as a vaccine for CRC patients.
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DOI:
--
发表时间:
1985
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
Herlyn,D;Powe,J;Ross,AH;Herlyn,M;Koprowski,H
通讯作者:
Koprowski,H
DOI:
--
发表时间:
1989
期刊:
Immunology series
影响因子:
--
作者:
GrafJr,LH;Ferrone,S
通讯作者:
Ferrone,S
DOI:
--
发表时间:
1988
影响因子:
11.1
作者:
C. Estin;U. Stevenson;G. Plowman;S. Hu;P. Sridhar;I. Hellström;J. Brown;K. Hellström
通讯作者:
K. Hellström
DOI:
10.1073/pnas.87.9.3542
发表时间:
1990-05-01
影响因子:
11.1
作者:
SZALA, S;FROEHLICH, M;LINNENBACH, AJ
通讯作者:
LINNENBACH, AJ
DOI:
10.1126/science.3952496
发表时间:
1986
期刊:
Science (New York, N.Y.)
影响因子:
--
作者:
Herlyn,D;Ross,AH;Koprowski,H
通讯作者:
Koprowski,H