Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches.
Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches.
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DOI：
10.1016/j.mib.2014.01.003
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发表时间：
2014-04
影响因子：
5.4
通讯作者：
Buxton, Roger S.
中科院分区：
文献类型：
--
作者：
Green, Jeffrey;Stapleton, Melanie R.;Smith, Laura J.;Artymiuk, Peter J.;Kahramanoglou, Christina;Hunt, Debbie M.;Buxton, Roger S.
大肠杆菌环磷酸腺苷受体蛋白(CRP)是一种基因调控的范例。比较CRP，发现它们对cAMP的亲和力不同。DNA结合对cAMP的依赖范围很大。CRP已经适应了细菌占据的特定生态位的功能。大肠埃希菌环磷酸腺苷受体蛋白(CRP)是细菌基因调控的典范之一。然而，尽管进行了数十年的密集研究，但新的信息不断涌现，促使人们重新评估这一经典的监管体系。此外，近年来，来自其他几个细菌物种的CRP已经被表征，使得CRP范例的普遍适用性得以测试。在这里，我们从大肠杆菌、结核分枝杆菌和恶臭假单胞菌的生态位的角度来考虑这些细菌的特性。看来，环磷酸腺苷-C反应蛋白调节系统已经适应了在一个广泛的敏感性范围内对不同的外部和内部输入做出反应，这至少部分由细菌的生活方式决定。
E. coli cyclic-AMP receptor protein (CRP) is a paradigm of gene regulation. Comparison of CRPs reveals differences in their affinity of cAMP. A range of dependency on cAMP for DNA-binding exists. CRPs have adapted to function in the specific niches occupied by the bacteria. Escherichia coli cyclic-AMP receptor protein (CRP) represents one of the paradigms of bacterial gene regulation. Yet despite decades of intensive study, new information continues to emerge that prompts reassessment of this classic regulatory system. Moreover, in recent years CRPs from several other bacterial species have been characterized, allowing the general applicability of the CRP paradigm to be tested. Here the properties of the E. coli, Mycobacterium tuberculosis and Pseudomonas putida CRPs are considered in the context of the ecological niches occupied by these bacteria. It appears that the cyclic-AMP-CRP regulatory system has been adapted to respond to distinct external and internal inputs across a broad sensitivity range that is, at least in part, determined by bacterial lifestyles.
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影响因子：
3.7
作者：
Shimada T;Fujita N;Yamamoto K;Ishihama A
通讯作者：
Ishihama A
结核分枝杆菌 cAMP 受体蛋白 (Rv3676) 与大肠杆菌范例的不同之处在于其 cAMP 结合和 DNA 结合特性以及转录激活特性。
DOI：
10.1074/jbc.m109.047720
发表时间：
2010-03-05
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Stapleton M;Haq I;Hunt DM;Arnvig KB;Artymiuk PJ;Buxton RS;Green J
通讯作者：
Green J
影响因子：
3.2
作者：
Bettenbrock, Katja;Sauter, Thomas;Gilles, Ernst-Dieter
通讯作者：
Gilles, Ernst-Dieter
影响因子：
5.1
作者：
Milanesio, Paola;Arce-Rodriguez, Alejandro;de Lorenzo, Victor
通讯作者：
de Lorenzo, Victor
DOI：
10.1073/pnas.0506687102
发表时间：
2005-12-06
影响因子：
11.1
作者：
Grainger, DC;Hurd, D;Busby, SJW
通讯作者：
Busby, SJW