Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms.
Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms.
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作者：
Chen S;Gan D;Lin S;Zhong Y;Chen M;Zou X;Shao Z;Xiao G
衰老是一个自然过程，在多种疾病的发病机制中起着关键作用，即，与衰老相关的疾病，如糖尿病、骨关节炎、阿尔茨海默病、心血管疾病、癌症、肥胖症和其他代谢异常。据报道，最广泛使用的抗糖尿病药物二甲双胍通过影响衰老的关键标志性事件（包括营养感知失调、蛋白质稳态丧失、线粒体功能障碍、细胞间通讯改变、端粒磨损、基因组不稳定性、表观遗传改变、干细胞耗竭和细胞衰老）来延缓衰老并对减缓各种衰老相关疾病的进展显示保护作用。本文就二甲双胍在预防和治疗衰老及衰老相关疾病中的应用作一综述。我们集中讨论二甲双胍在调节衰老和治疗衰老相关疾病中的作用和潜在机制。
Aging is a natural process, which plays a critical role in the pathogenesis of a variety of diseases, i.e., aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease, cardiovascular diseases, cancers, obesity and other metabolic abnormalities. Metformin, the most widely used antidiabetic drug, has been reported to delay aging and display protective effect on attenuating progression of various aging-related diseases by impacting key hallmark events of aging, including dysregulated nutrient sensing, loss of proteostasis, mitochondrial dysfunction, altered intercellular communication, telomere attrition, genomic instability, epigenetic alterations, stem cell exhaustion and cellular senescence. In this review, we provide updated information and knowledge on applications of metformin in prevention and treatment of aging and aging-related diseases. We focus our discussions on the roles and underlying mechanisms of metformin in modulating aging and treating aging-related diseases.
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影响因子：
6.2
作者：
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5
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3.1
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