The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer.
The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer.
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DOI：
10.1016/j.critrevonc.2013.01.005
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发表时间：
2013-09
影响因子：
6.2
通讯作者：
Bartke, Andrzej
中科院分区：
文献类型：
--
作者：
Anisimov, Vladimir N.;Bartke, Andrzej
对哺乳动物的研究表明，高血糖和高胰岛素血症是衰老的重要因素。与长寿有关的GH/胰岛素/胰岛素样生长因子1 （IGF-1）信号分子包括daf-2和InR及其在哺乳动物中的同源物，而在线虫、果蝇和小鼠中，相应基因的失活可以延长寿命。热量限制的延寿效果可能与降低IGF-1水平有关。有证据表明，抗糖尿病药物是延长寿命和预防癌症的有希望的候选药物。因此，抗糖尿病药物延缓小鼠和大鼠的自发癌变，以及小鼠、大鼠和仓鼠的化学和辐射癌变。此外，二甲双胍似乎可以降低糖尿病患者患癌症的风险。
Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors in aging. GH/Insulin/insulin-like growth factor 1 (IGF-1) signaling molecules that have been linked to longevity include daf-2 and InR and their homologues in mammals, and inactivation of the corresponding genes increases lifespan in nematodes, fruit flies and mice. The life-prolonging effects of caloric restriction are likely related to decreasing IGF-1 levels. Evidence has emerged that antidiabetic drugs are promising candidates for both lifespan extension and prevention of cancer. Thus, antidiabetic drugs postpone spontaneous carcinogenesis in mice and rats, as well as chemical and radiation carcinogenesis in mice, rats and hamsters. Furthermore, metformin seems to decrease the risk for cancer in diabetic patients.
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DOI：
10.18632/aging.100273
发表时间：
2011-02
期刊：
Aging
影响因子：
--
作者：
Anisimov VN;Berstein LM;Popovich IG;Zabezhinski MA;Egormin PA;Piskunova TS;Semenchenko AV;Tyndyk ML;Yurova MN;Kovalenko IG;Poroshina TE
通讯作者：
Poroshina TE
影响因子：
4.8
作者：
Al-Regaiey, KA;Masternak, MM;Bartke, A
通讯作者：
Bartke, A
影响因子：
5.8
作者：
Aguiar-Oliveira, Manuel H.;Oliveira, Francielle T.;Salvatori, Roberto
通讯作者：
Salvatori, Roberto
影响因子：
3.9
作者：
Anisimov, VN;Berstein, LM;Franceschi, C
通讯作者：
Franceschi, C
DOI：
10.1016/j.tem.2009.11.005
发表时间：
2010-03
期刊：
Trends in endocrinology and metabolism: TEM
影响因子：
--
作者：
Anderson RM;Weindruch R
通讯作者：
Weindruch R