Anterior EEG asymmetry and the Modifier Model of Autism.
Anterior EEG asymmetry and the Modifier Model of Autism.
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DOI：
10.1007/s10803-010-1138-0
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发表时间：
2011-08
影响因子：
3.9
通讯作者：
Mundy, Peter C.
中科院分区：
文献类型：
--
作者：
Burnette, Courtney P.;Henderson, Heather A.;Inge, Anne Pradella;Zahka, Nicole E.;Schwartz, Caley B.;Mundy, Peter C.
自闭症表现的个体差异使对这种疾病的性质和治疗的研究复杂化。在自闭症的修饰者模型(Mundy等人)中，我们提出自闭症的个体差异可能不仅是症状特定的因果过程造成的，还可能是影响所有人的社会和情感发展的一般的、非症状特定的修饰过程的差异性造成的。一项支持这一模型的研究发现，静息前脑电不对称性的测量反映了与一般个体在接近和回避动机上的差异相关的复杂大脑过程，这可能有助于解释非智力残疾儿童自闭症表现的差异(Sutton等人)。在目前的研究中，我们部分复制了观察到的观察结果，即表现出左侧额叶脑电不对称模式的自闭症儿童往往表现出较轻微的社会症状，尽管在当前的样本中，这种模式仅适用于言语智商相对较低的HFA儿童。新的观察表明，左侧额叶脑电不对称也与父母回顾报告的症状出现年龄显著较晚有关，但也与自闭症儿童在学龄期功能较高的儿童中更高水平的愤怒自我报告和强迫症症状有关。因此，这项研究的结果提供了一组新的和完全独立的观察结果，表明前部脑电不对称的个体差异可能显著缓和自闭症的表现和发展过程。这一观察结果可能对确定自闭症儿童中有意义的诊断亚群具有临床意义。
Individual differences in the expression of autism complicate research on the nature and treatment of this disorder. In the Modifier Model of Autism (Mundy et al.), we proposed that individual differences in autism may result not only from syndrome specific causal processes, but also from variability in generic, non-syndrome specific modifier processes that affect the social and emotional development of all people. One study supporting this model found that measures of resting anterior EEG asymmetry, a measure reflecting complex brain processes associated with generic individual differences in approach and avoidance motivation, may help explain differences in the expression of autism in children without intellectual disabilities (Sutton et al.). In the current study, we partially replicated the observation that children with autism who exhibited a pattern of left frontal EEG asymmetry tended to display milder levels of social symptoms, although in the current sample this pattern applied only to HFA children with relatively lower verbal IQs. New observations indicated that left frontal EEG asymmetry was also associated with retrospective parent reports of significantly later age of onset of symptoms, but also higher levels of self-reported outward expressions of anger as well as symptoms of obsessive compulsive disorder in school-age higher functioning children with ASD. Therefore, the results of this study provide a new and fully independent set of observations, which indicate that individual differences in anterior EEG asymmetry may significantly moderate the expression and developmental course of autism. This observation may have clinical implications for identifying meaningful diagnostic sub-groups among children with autism.
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影响因子：
10.6
作者：
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通讯作者：
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DOI：
10.1111/j.1469-7610.2007.01762.x
发表时间：
2007-09-01
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