Centrally administered histamine evokes the adrenal secretion of noradrenaline and adrenaline by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats.
Centrally administered histamine evokes the adrenal secretion of noradrenaline and adrenaline by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats.
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集中施用组胺可通过大鼠大脑环氧合酶 1 和血栓素 A2 介导的机制诱发去甲肾上腺素和肾上腺素的肾上腺分泌。
DOI：
10.1016/j.ejphar.2006.05.013
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发表时间：
2006
影响因子：
5
通讯作者：
K. Yokotani
中科院分区：
文献类型：
--
作者：
Takahiro Shimizu;S. Okada;Naoko Yamaguchi;Tsuyoshi Sasaki;Lianyi Lu;K. Yokotani
血浆肾上腺素来源于肾上腺髓质，血浆去甲肾上腺素除肾上腺髓质分泌外，还反映交感神经的释放。本研究旨在描述由中央给药组胺诱导的血浆儿茶酚胺的来源，关于脑前列腺素。脑室内给药组胺（1、5和10 μg/只）使血浆去甲肾上腺素和肾上腺素（去甲肾上腺素<肾上腺素）呈剂量依赖性升高。酮洛芬（环氧化酶-1的选择性抑制剂）（100、250和500 μg/只动物，体外循环）剂量依赖性地降低组胺（5 μg/只动物，体外循环）诱导的两种儿茶酚胺升高，而NS-398（环氧化酶-2的选择性抑制剂）（250和500 μg/只动物，体外循环）没有作用。组胺诱导的反应被furegurelate（一种血栓素a2合成酶抑制剂）（250和500 μg/只，i.c.v）剂量依赖性地减弱，并通过急性双侧肾上腺切除术消除。这些结果表明，在大鼠中，中央给药组胺通过脑环氧化酶-1和血栓素a2介导的机制唤起血浆去甲肾上腺素和肾上腺髓质的肾上腺素。
Plasma adrenaline is originated from adrenal medulla, while plasma noradrenaline reflects the release from sympathetic nerves in addition to the secretion from adrenal medulla. The present study was designed to characterize the source of plasma catecholamines induced by centrally administered histamine, with regard to the brain prostanoids. Intracerebroventricularly (i.c.v.) administered histamine (1, 5 and 10 μg/animal) elevated plasma noradrenaline and adrenaline (noradrenaline<adrenaline) in a dose-dependent manner. Ketoprofen (a selective inhibitor of cyclooxygenase-1) (100, 250 and 500 μg/animal, i.c.v.) dose-dependently reduced the histamine (5 μg/animal, i.c.v.)-induced elevation of both catecholamines, while NS-398 (a selective inhibitor of cyclooxygenase-2) (250 and 500 μg/animal, i.c.v.) had no effect. The histamine-induced response was dose-dependently attenuated by furegurelate (an inhibitor of thromboxane A2synthase) (250 and 500 μg/animal, i.c.v.), and abolished by acute bilateral adrenalectomy. These results suggest that centrally administered histamine evokes plasma noradrenaline and adrenaline from adrenal medulla by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats.
通过微透析在清醒大鼠中测量低血糖时肾上腺素和去甲肾上腺素的释放。
DOI：
10.1152/ajpregu.1997.273.5.r1758
发表时间：
1997
期刊：
The American journal of physiology
影响因子：
--
作者：
Vollmer,RR;Balcita,JJ;Sved,AF;Edwards,DJ
通讯作者：
Edwards,DJ
脑前列腺素在控制清醒大鼠加压素分泌中的作用。
影响因子：
4.8
作者：
Brooks,DP;Share,L;Crofton,JT
通讯作者：
Crofton,JT