Adrenal epinephrine and norepinephrine release to hypoglycemia measured by microdialysis in conscious rats.
Adrenal epinephrine and norepinephrine release to hypoglycemia measured by microdialysis in conscious rats.
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通过微透析在清醒大鼠中测量低血糖时肾上腺素和去甲肾上腺素的释放。
DOI：
10.1152/ajpregu.1997.273.5.r1758
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Edwards,DJ
中科院分区：
文献类型：
--
作者：
Vollmer,RR;Balcita,JJ;Sved,AF;Edwards,DJ
在清醒的雄性大鼠中进行实验，以确定胰岛素给药诱导的低血糖是否优先刺激肾上腺素（Epi）或去甲肾上腺素（NE）肾上腺髓质嗜铬细胞。肾上腺髓质释放的肾上腺素和NE连续监测使用微透析探针的新设计，已插入肾上腺髓质16小时前胰岛素给药。静脉注射3 U/kg胰岛素后，血糖下降，透析液Epi水平升高。未获得透析液NE的可测量增量。类似地，血浆Epi增加，NE未检测到变化。在胰岛素治疗前喂食或禁食过夜的两组动物中，透析液和血浆儿茶酚胺变化的模式相似。然而，禁食动物的Epi增加幅度更大。血糖浓度恢复至胰岛素前水平后，透析液和血浆儿茶酚胺浓度恢复至对照值。这些实验清楚地表明，产生Epi的肾上腺髓质嗜铬细胞在胰岛素诱导的低血糖反应中优先受到刺激。
Experiments were conducted in conscious male rats to determine whether hypoglycemia induced by insulin administration preferentially stimulated epinephrine (Epi) or norepinephrine (NE) adrenal medullary chromaffin cells. The release of Epi and NE from the adrenal medulla was continuously monitored using a microdialysis probe of novel design that had been inserted in the adrenal medulla ∼16 h before the administration of insulin. Following insulin, 3 U/kg iv, blood glucose declined and dialysate Epi levels rose. No measurable increment in dialysate NE was obtained. Similarly, plasma Epi increased with no detectable change in NE. Patterns of dialysate and plasma catecholamine changes were similar in two groups of animals that had been fed or fasted overnight before insulin treatment. However, the magnitude of the Epi increase was greater in the fasted animals. After recovery of the blood glucose concentration to preinsulin levels, dialysate and plasma catecholamine concentrations returned to control values. These experiments clearly demonstrate that adrenal medullary chromaffin cells that produce Epi are preferentially stimulated in response to insulin-induced hypoglycemia.
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不同肾上腺髓质细胞中存在肾上腺素和去甲肾上腺素的证据。
DOI：
--
发表时间：
1953
期刊：
Acta Physiologica Scandinavica
影响因子：
--
作者：
Nils;Bernt Hökfelt
通讯作者：
Bernt Hökfelt
影响因子：
--
作者：
VOLLMER, RR;BARUCHIN, A;KAPLAN, BB
通讯作者：
KAPLAN, BB
影响因子：
3.3
作者：
Edwards, SL;Anderson, CR;McAllen, RM
通讯作者：
McAllen, RM
葡萄糖、胰岛素和交感肾上腺激活。
DOI：
10.1016/0165-1838(87)90152-4
发表时间：
1987
期刊：
Journal of the autonomic nervous system
影响因子：
--
作者：
Levin,BE;Sullivan,AC
通讯作者：
Sullivan,AC
胰岛素应激引起的血浆儿茶酚胺升高受到神经元和非神经元的控制。
影响因子：
4.8
作者：
Zeinab Khalil;Philip D. Marley;B. G. Livett
通讯作者：
B. G. Livett