Spatial distribution of suppressive signals outside the classical receptive field in lateral geniculate nucleus.
Spatial distribution of suppressive signals outside the classical receptive field in lateral geniculate nucleus.
复制标题
外侧膝状核经典感受野外抑制信号的空间分布。
DOI：
--
复制
发表时间：
2005
影响因子：
2.5
通讯作者：
A. Derrington
中科院分区：
文献类型：
--
作者：
B. Webb;Chris J. Tinsley;C. Vincent;A. Derrington
抑制性周围环境调节外侧膝状核（LGN）细胞的反应性，但我们对其空间结构或其组合来自不同位置的信号的方式一无所知。通常假设抑制信号在感受野之外的相对区域中均匀分布或平衡。在这里，我们检查了麻醉狨猴 46 个 LGN 细胞的细胞外记录中感受野外抑制信号的空间分布和总和。每个细胞的感受野受到首选尺寸和空间和时间频率的漂移正弦光栅的刺激；我们使用首选空间和时间频率的大半环形光栅或小圆形光栅贴片探测抑制环绕中的不同位置。在许多具有强抑制周围的细胞（29/46）中，抑制的空间分布显示出明显偏离圆形对称性。在大多数细胞中，抑制信号在感受野之外的相对区域中空间不对称或平衡。抑制区域大于经典感受野本身，并且这些区域内和之间的空间总和是非线性的。中心凹或鼻部视网膜的视锥细胞密度较高，且抑制性周围没有其他系统空间组织的迹象，因此不存在抑制偏差。我们得出结论，LGN 中的非经典抑制信号偏离圆形对称性并且是非线性组合的。
A suppressive surround modulates the responsiveness of cells in the lateral geniculate nucleus (LGN), but we know nothing of its spatial structure or the way in which it combines signals arising from different locations. It is generally assumed that suppressive signals are either uniformly distributed or balanced in opposing regions outside the receptive field. Here, we examine the spatial distribution and summation of suppressive signals outside the receptive field in extracellular recordings from 46 LGN cells in anesthetized marmosets. The receptive field of each cell was stimulated with a drifting sinusoidal grating of the preferred size and spatial and temporal frequency; we probed different positions in the suppressive surround with either a large half-annular grating or a small circular grating patch of the preferred spatial and temporal frequency. In many of the cells with a strong suppressive surround (29/46), the spatial distribution of suppression showed clear deviation from circular symmetry. In the majority of these of cells, suppressive signals were spatially asymmetrical or balanced in opposing areas outside the receptive field. A suppressive area was larger than the classical receptive field itself and spatial summation within and between these areas was nonlinear. There was no bias for suppression to arise from foveal or nasal retina where cone density is higher and no other sign of a systematic spatial organization to the suppressive surround. We conclude that nonclassical suppressive signals in LGN deviate from circular symmetry and are nonlinearly combined.
登录
查看更多内容
影响因子：
2.5
作者：
Cavanaugh, JR;Bair, W;Movshon, JA
通讯作者：
Movshon, JA
影响因子：
--
作者：
A. Angelucci;J. B. Levitt;J. Lund
通讯作者：
A. Angelucci;J. B. Levitt;J. Lund
DOI：
10.1113/jphysiol.1984.sp015103
发表时间：
1984-03
期刊：
The Journal of Physiology
影响因子：
--
作者：
J. W. McClurkin;R. Marrocco
通讯作者：
J. W. McClurkin;R. Marrocco
影响因子：
2.5
作者：
James R. Müller;A. Metha;J. Krauskopf;P. Lennie
通讯作者：
James R. Müller;A. Metha;J. Krauskopf;P. Lennie
影响因子：
5.5
作者：
DERRINGTON, AM;LENNIE, P
通讯作者：
LENNIE, P