Prospective longitudinal patient-reported outcomes of swallowing following intensity modulated proton therapy for oropharyngeal cancer.
Prospective longitudinal patient-reported outcomes of swallowing following intensity modulated proton therapy for oropharyngeal cancer.
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DOI：
10.1016/j.radonc.2020.04.021
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发表时间：
2020-07
影响因子：
5.7
通讯作者：
Frank, Steven J.
中科院分区：
文献类型：
--
作者：
Grant, Stephen R.;Hutcheson, Katherine A.;Ye, Rong;Garden, Adam S.;Morrison, William H.;Rosenthal, David, I;Gunn, G. Brandon;Fuller, C. David;Phan, Jack;Reddy, Jay P.;Moreno, Amy C.;Lewin, Jan S.;Sturgis, Erich M.;Ferrarotto, Renata;Frank, Steven J.
随着口咽癌长期存活者人数的增加，吞咽困难是口咽癌治疗后日益重要的毒性反应。虽然与基于光子的放射治疗相比，调强质子治疗(IMPT)对正常周围结构的剂量可能更低，但其临床益处尚不确定。纳入71名正在接受纵向前瞻性队列研究的III/IV期口咽癌患者，他们在预先指定的时间点完成了MD Anderson吞咽困难调查(MDADI)。大多数患者有HPV阳性肿瘤(85.9%)，接受双侧颈部放射治疗(81.4%)，同时进行系统治疗(61.8%)。平均综合MDADI评分从治疗前的88.2分降至治疗6周的59.6分，10周后升至74.4分，6个月时为77.0分，12个月时为80.5分，24个月时为80.1分。基线时，只有5.6%的患者综合评分较差(低于60分)，相比之下，治疗6周时为61.2%，10周时为19.1%，6个月时为13.0%，1年时为13.5%，2年时为11.1%。患者报告口咽癌IMPT治疗后的结果显示，治疗结束时吞咽功能下降，相对较快地恢复了10周的随访，并在2年内稳步改善。这些结果与口咽癌光子放射治疗的类似纵向研究类似，并表明IMPT没有与吞咽有关的额外毒性。
With an enlarging population of long-term oropharyngeal cancer survivors, dysphagia is an increasingly important toxicity following oropharynx cancer treatment. While lower doses to normal surrounding structures may be achieved with intensity modulated proton therapy (IMPT) compared to photon-based radiation, the clinical benefit is uncertain. Seventy-one patients with stage III/IV oropharyngeal cancer undergoing definitive IMPT on a longitudinal prospective cohort study who had completed the MD Anderson Dysphagia Inventory (MDADI) at pre-specified time points were included. The majority of patients had HPV-positive tumors (85.9%) and received bilateral neck radiation (81.4%) with concurrent systemic therapy (61.8%). Mean composite MDADI scores decreased from 88.2 at baseline to 59.6 at treatment week 6, and then increased to 74.4 by follow up week 10, 77.0 by 6 months follow up, 80.5 by 12 months follow up, and 80.1 by 24 months follow up. At baseline, only 5.6% of patients recording a poor composite score (lower than 60), compared to 61.2% at treatment week 6, 19.1% at follow up week 10, 13.0% at 6 months follow up, 13.5% at 1 year follow up, and 11.1% at 2 years follow up. Patient reported outcomes following IMPT for oropharyngeal cancer demonstrates decreased swallowing function at completion of treatment with relatively rapid recovery by 10 weeks follow up and steady improvement through 2 years. The results are comparable to similar longitudinal studies of photon-based radiotherapy for oropharynx cancer, and suggest that IMPT confers no additional excess toxicity related to swallowing.
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DOI：
10.1016/j.ijrobp.2016.02.021
发表时间：
2016-05-01
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Gunn GB;Blanchard P;Garden AS;Zhu XR;Fuller CD;Mohamed AS;Morrison WH;Phan J;Beadle BM;Skinner HD;Sturgis EM;Kies MS;Hutcheson KA;Rosenthal DI;Mohan R;Gillin MT;Frank SJ
通讯作者：
Frank SJ
DOI：
10.1016/j.radonc.2016.08.022
发表时间：
2016-12
期刊：
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
影响因子：
--
作者：
Blanchard P;Wong AJ;Gunn GB;Garden AS;Mohamed ASR;Rosenthal DI;Crutison J;Wu R;Zhang X;Zhu XR;Mohan R;Amin MV;Fuller CD;Frank SJ
通讯作者：
Frank SJ
影响因子：
5.7
作者：
Bhide, Shreerang A.;Gulliford, Sarah;Nutting, Christopher M.
通讯作者：
Nutting, Christopher M.
影响因子：
6.2
作者：
Hutcheson, Katherine A.;Lewin, Jan S.;Barringer, Denise A.;Lisec, Asher;Gunn, G. Brandon;Moore, Michael W. S.;Holsinger, F. Christopher
通讯作者：
Holsinger, F. Christopher
影响因子：
4.8
作者：
Peng, Luke C.;Hui, Xuan;Quon, Harry
通讯作者：
Quon, Harry