High-resolution functional connectivity of the default mode network in young adults with down syndrome.
High-resolution functional connectivity of the default mode network in young adults with down syndrome.
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DOI：
10.1007/s11682-020-00399-z
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发表时间：
2021-08
影响因子：
3.2
通讯作者：
Leverenz JB
中科院分区：
文献类型：
--
作者：
Koenig KA;Bekris LM;Ruedrich S;Weber GE;Khrestian M;Oh SH;Kim S;Wang ZI;Leverenz JB
阿尔茨海默病的静息态功能连接MRI研究表明，疾病阶段在默认模式网络的功能变化中发挥作用。患有遗传性疾病唐氏综合征的个体显示出早发性阿尔茨海默型痴呆的发病率增加，沿着阿尔茨海默病的早期和几乎普遍的神经病理学变化。本研究检查了11名唐氏综合征年轻人的默认模式网络的高分辨率功能连接，这些唐氏综合征没有表现出可测量的痴呆症状，11名年龄和性别匹配的神经典型对照。我们专注于默认模式网络的网络内连接，从扣带皮层的前部和后部测量。在唐氏综合征组中，68%的后扣带回连接和26%的前扣带回连接强度降低（p < 0.01）。唐氏综合征组从扣带回前部到双侧额下回和右侧壳核的连接强度增加（p < 0.005）。在一项探索性分析中，唐氏综合征组的连通性显示出与炎症标志物和t-tau的血浆测量的区域关系。在患有唐氏综合征的非痴呆成年人中，默认模式网络内的功能连接可能类似于临床前阿尔茨海默病中报告的变化，并需要进一步研究作为痴呆风险的衡量标准。
Studies of resting-state functional connectivity MRI in Alzheimer’s disease suggest that disease stage plays a role in functional changes of the default mode network. Individuals with the genetic disorder Down syndrome show an increased incidence of early-onset Alzheimer’s-type dementia, along with early and nearly universal neuropathologic changes of Alzheimer’s disease. The present study examined high-resolution functional connectivity of the default mode network in 11 young adults with Down syndrome that showed no measurable symptoms of dementia and 11 age- and sex-matched neurotypical controls. We focused on within-network connectivity of the default mode network, measured from both anterior and posterior aspects of the cingulate cortex. Sixty-eight percent of connections to the posterior cingulate and 26% to the anterior cingulate showed reduced strength in the group with Down syndrome (p < 0.01). The Down syndrome group showed increased connectivity strength from the anterior cingulate to the bilateral inferior frontal gyri and right putamen (p < 0.005). In an exploratory analysis, connectivity in the group with Down syndrome showed regional relationships to plasma measures of inflammatory markers and t-tau. In non-demented adults with Down syndrome, functional connectivity within the default mode network may be analogous to changes reported in preclinical Alzheimer’s disease, and warrants further investigation as a measure of dementia risk.
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影响因子：
10.5
作者：
Deb, Shoumitro;Hare, Monika;Bhaumik, Sabyasachi
通讯作者：
Bhaumik, Sabyasachi
影响因子：
4.2
作者：
Anderson, Jeffrey S.;Nielsen, Jared A.;Ferguson, Michael A.;Burback, Melissa C.;Cox, Elizabeth T.;Dai, Li;Gerig, Guido;Edgin, Jamie O.;Korenberg, Julie R.
通讯作者：
Korenberg, Julie R.
DOI：
10.1111/j.1365-2788.2006.00902.x
发表时间：
2007-06-01
影响因子：
3.6
作者：
Margallo-Lana, M. L.;Moore, P. B.;Tyrer, S. P.
通讯作者：
Tyrer, S. P.
影响因子：
5.7
作者：
Marques, Jose P.;Kober, Tobias;Gruetter, Rolf
通讯作者：
Gruetter, Rolf
影响因子：
14
作者：
Iulita, M. Florencia;Ower, Alison;Cuello, A. Claudio
通讯作者：
Cuello, A. Claudio