Abnormal brain synchrony in Down Syndrome.
Abnormal brain synchrony in Down Syndrome.
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DOI：
10.1016/j.nicl.2013.05.006
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发表时间：
2013
影响因子：
4.2
通讯作者：
Korenberg, Julie R.
中科院分区：
文献类型：
--
作者：
Anderson, Jeffrey S.;Nielsen, Jared A.;Ferguson, Michael A.;Burback, Melissa C.;Cox, Elizabeth T.;Dai, Li;Gerig, Guido;Edgin, Jamie O.;Korenberg, Julie R.
唐氏综合症是智力残疾最常见的遗传原因，但唐氏综合症中认知障碍的病理生理学尚不清楚。我们比较了15名唐氏综合症患者和14名正常发育的对照组的fMRI扫描，同时他们观看了50分钟的卡通视频剪辑。在唐氏综合症患者中，大脑区域之间的同步性普遍增强，只有一小部分强而远的连接显示出连接不足。显示负相关性的大脑区域与神经元的相关性较低，并且是大脑中受影响最严重的连接之一。在所有被研究的分布式大脑网络之间观察到增加的相关性，在具有最低性能智商的受试者中具有最强的网络间相关性。唐氏综合症患者的大脑功能分区显示出由局部连接组织的简化网络结构。尽管增加区域间的同步性，主题间的相关性的卡通刺激是较低的唐氏综合症，表明增加同步性的时间模式，是不是在响应环境刺激，但特异性的每个唐氏综合症的主题。从自闭症脑成像交换（ABIDE）收集的静息状态fMRI数据中，在447名自闭症患者与517名对照受试者的比较样本中没有观察到短程同步性增加，并且仅在自闭症的默认模式和注意力网络之间观察到网络间同步性增加。这些发现表明唐氏综合症患者的连接发育不成熟，将来自遥远大脑区域的信息整合到连贯的分布式网络的能力受损。唐氏综合症患者相邻的大脑区域更加同步。唐氏综合症患者大脑中较远的区域同步性较差。在唐氏综合症中，负相关的大脑区域与大脑的相关性较低。唐氏综合症受试者表现出简化的大脑网络架构。大脑同步性的增加并不反映对环境刺激的反应。
Down Syndrome is the most common genetic cause for intellectual disability, yet the pathophysiology of cognitive impairment in Down Syndrome is unknown. We compared fMRI scans of 15 individuals with Down Syndrome to 14 typically developing control subjects while they viewed 50 min of cartoon video clips. There was widespread increased synchrony between brain regions, with only a small subset of strong, distant connections showing underconnectivity in Down Syndrome. Brain regions showing negative correlations were less anticorrelated and were among the most strongly affected connections in the brain. Increased correlation was observed between all of the distributed brain networks studied, with the strongest internetwork correlation in subjects with the lowest performance IQ. A functional parcellation of the brain showed simplified network structure in Down Syndrome organized by local connectivity. Despite increased interregional synchrony, intersubject correlation to the cartoon stimuli was lower in Down Syndrome, indicating that increased synchrony had a temporal pattern that was not in response to environmental stimuli, but idiosyncratic to each Down Syndrome subject. Short-range, increased synchrony was not observed in a comparison sample of 447 autism vs. 517 control subjects from the Autism Brain Imaging Exchange (ABIDE) collection of resting state fMRI data, and increased internetwork synchrony was only observed between the default mode and attentional networks in autism. These findings suggest immature development of connectivity in Down Syndrome with impaired ability to integrate information from distant brain regions into coherent distributed networks. Adjacent brain regions are more synchronized in Down Syndrome. Distant brain regions show less synchronization in Down Syndrome. Negatively correlated brain regions are less anticorrelated in Down Syndrome. Down Syndrome subjects show simplified brain network architecture. Increased brain synchrony does not reflect a response to environmental stimuli.
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作者：
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DOI：
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