Treatment of Persistent Gross Hematuria with Tranexamic Acid in Autosomal Dominant Polycystic Kidney Disease
Treatment of Persistent Gross Hematuria with Tranexamic Acid in Autosomal Dominant Polycystic Kidney Disease
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氨甲环酸治疗常染色体显性多囊肾病持续性肉眼血尿
DOI：
10.1159/000474961
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发表时间：
2017-04
影响因子：
2.8
通讯作者：
Mei Changlin
中科院分区：
文献类型：
--
作者：
Yao Qing;Wu Ming;Zhou Jie;Zhou Meiyang;Chen Dongping;Fu Lili;Bian Rongrong;Xing Xiaohong;Sun Lijun;Hu Xiaohong;Li Lin;Dai Bing;Wuthrich Rudolf P.;Ma Yiyi;Mei Changlin
背景/目标：在这项回顾性研究中，我们旨在比较氨甲环酸（TXA）与酚磺乙胺（两种止血剂）对常染色体显性多囊肾病（ADPKD）伴持续肉眼血尿患者血尿持续时间的影响。方法：回顾性分析40例有肉眼血尿的ADPKD患者的临床资料。对20例接受血栓素A和蛇毒凝血酶注射液治疗的患者与20例接受酚磺乙胺和蛇毒凝血酶注射液治疗的患者进行比较。主要结局是血尿持续时间，次要结局是输血需求和不良事件。结果：TXA组血尿持续时间较酚磺乙胺组短（4[3-5] d比7[6-10] d，P<0.001）。TXA组的输血量倾向于少于酚磺乙胺组（300±115 ml vs 486±195 ml，P=0.12），需要输血的患者数量也倾向于较低[20%（4/20）vs 35%（7/20），P=0.29]。TXA和酚磺乙胺的耐受性同样良好，两组均未观察到严重不良事件。结论：我们的研究表明，TXA治疗ADPKD患者持续肉眼血尿的止血效果优于酚磺乙胺。
Background/Aims: In this retrospective study we aimed to compare the effect of tranexamic acid (TXA) vs etamsylate, two hemostatic agents, on hematuria duration in autosomal dominant polycystic kidney disease (ADPKD) patients with persistent gross hematuria. Methods: This is a retrospective study of 40 patients with ADPKD and macroscopic hematuria. 20 patients receiving TXA and snake venom blood clotting enzyme injection were compared with 20 matched patients receiving etamsylate and snake venom blood clotting enzyme injection. The primary outcome was hematuria duration and the secondary outcomes were blood transfusion requirements and adverse events. Results: The hematuria duration was shorter in the TXA group compared with the etamsylate group (4[3-5] d vs 7[6-10] d, P<0.001). The volume of blood transfusion tended to be less in the TXA group than in the etamsylate group (300±115 ml vs 486±195 ml, P=0.12), and the number of patients needing a blood transfusion also tended to be lower [20% (4/20) vs 35% (7/20), P=0.29]. TXA and etamsylate were equally well tolerated and no serious adverse events were observed in both groups. Conclusions: Our study indicates that TXA treatment was more effective than etamsylate in stopping bleeding in ADPKD patients with persistent gross hematuria.
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白藜芦醇通过减弱核因子 kappa B 诱导的炎症来延缓多囊肾病的进展
影响因子：
6.1
作者：
Wu Ming;Gu Junhui;Mei Shuqin;Xu Dechao;Jing Ying;Yao Qing;Chen Meihan;Yang Ming;Chen Sixiu;Yang Bo;Qi Na;Hu Huimin;Wuthrich Rudolf P.;Mei Changlin
通讯作者：
Mei Changlin
影响因子：
2.8
作者：
Masoumi A;Reed-Gitomer B;Kelleher C;Bekheirnia MR;Schrier RW
通讯作者：
Schrier RW
DOI：
10.1016/b978-0-323-05876-6.00044-7
发表时间：
2003
期刊：
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
影响因子：
--
作者：
V. Torres;P. Harris
通讯作者：
V. Torres;P. Harris
影响因子：
3.2
作者：
R. Wüthrich;C. Mei
通讯作者：
R. Wüthrich;C. Mei
影响因子：
6.1
作者：
Koo, JR;Lee, YK;Won, NH
通讯作者：
Won, NH