The influence of dose and dosing interval on MPTP-induced dopaminergic neurotoxicity in mice.
The influence of dose and dosing interval on MPTP-induced dopaminergic neurotoxicity in mice.
复制标题
剂量和给药间隔对 MPTP 诱导的小鼠多巴胺能神经毒性的影响。
DOI：
10.1016/0014-2999(86)90444-9
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发表时间：
1986
影响因子：
5
通讯作者：
R. Heikkila
中科院分区：
文献类型：
--
作者：
P. Sonsalla;R. Heikkila
在C57-black和CF-W白化病小鼠中研究了1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）给药的不同给药模式的影响。几组小鼠接受以每次注射不同剂量和/或以不同时间间隔施用的总剂量为80 mg/kg的MPTP。在C57-黑小鼠中，MPTP给药对多巴胺新纹状体含量的影响范围从91%耗竭（每次注射20 mg/kg，间隔1 h注射4次）至非显著影响（连续2天，每次注射10 mg/kg，间隔2 h注射4次）。在CF-W小鼠中，每次注射的MPTP剂量和给药间隔也有相当大的影响，尽管CF-W小鼠中新纹状体多巴胺耗竭的程度不如在C57-black小鼠中观察到的那么大。此外，MPTP对不同品系小鼠以及不同来源的Swiss-Webster小鼠的新纹状体多巴胺水平产生了不同的影响。一些菌株受到很大程度的影响，而其他菌株仅受到轻微影响。
The effects of different dosing paradigms for the administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were investigated in C57-black and CF-W albino mice. Several groups of mice received a total dose of 80 mg/kg of MPTP administered at different doses per injection and/or at different time intervals. In C57-black mice, the effects of MPTP administration on the neostriatal content of dopamine ranged from a 91% depletion (4 injections of 20 mg/kg per injection at 1 h intervals) to a non-significant effect (4 injections of 10 mg/kg per injection at 2 h intervals on each of 2 successive days). There was also considerable influence of the MPTP dose per injection and the dosing interval in CF-W mice, although the extent of neostriatal dopamine depletion in CF-W mice was not as great as that observed in C57-black mice. In addition, MPTP produced variable effects on neostriatal dopamine levels in different strains of mice as well as in Swiss-Webster mice obtained from different sources. Some of the strains were affected to a great extent while others were only marginally affected.
影响因子：
56.9
作者：
DAMATO, RJ;LIPMAN, ZP;SNYDER, SH
通讯作者：
SNYDER, SH
DOI：
10.1073/pnas.82.7.2173
发表时间：
1985-01-01
影响因子：
11.1
作者：
JAVITCH, JA;DAMATO, RJ;SNYDER, SH
通讯作者：
SNYDER, SH