Cognitive deficits following anti-NMDA receptor encephalitis.
Cognitive deficits following anti-NMDA receptor encephalitis.
复制标题
DOI：
10.1136/jnnp-2011-300411
复制
发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Ploner CJ
中科院分区：
文献类型：
--
作者：
Finke C;Kopp UA;Prüss H;Dalmau J;Wandinger KP;Ploner CJ
抗 NMDA 受体（NMDAR）脑炎是一种最近被描述的自身免疫性疾病，主要影响年轻女性。尽管这种急性疾病的临床特征已得到很好的表征，但认知的长期结果尚未得到详细研究。作者调查了 9 名已证实患有抗 NMDAR 脑炎的患者从急性疾病期（发病后中位 43 个月，范围 23 至 69 个月）恢复后的认知表现。患者接受了全面的神经心理学评估，包括先前已被证明对海马功能障碍敏感的记忆任务。九名患者中有八人观察到严重的持续性认知障碍，主要包括执行功能和记忆力缺陷。这些缺陷的严重程度因人而异。接受早期免疫治疗的患者表现明显更好。最严重的缺陷是由于初始治疗效率低下或延迟而观察到的。我们的结果表明认知缺陷构成抗 NMDAR 脑炎的主要长期发病率。这些缺陷与 NMDAR 在人脑中的分布及其在正常认知中的功能作用有关。良好的认知长期结果可能取决于早期和积极的治疗。
Anti-NMDA receptor (NMDAR) encephalitis is a recently characterised autoimmune disorder mainly affecting young women. Although the clinical features of the acute disease are well characterised, cognitive long-term outcome has not been examined in detail. The authors investigated cognitive performance in nine patients with proven anti-NMDAR encephalitis after recovery from the acute disease period (median 43 months after disease onset, range 23 to 69). Patients underwent a comprehensive neuropsychological assessment, including memory tasks that have previously been shown to be sensitive for hippocampal dysfunction. Substantial persistent cognitive impairments were observed in eight out of nine patients that mainly consisted of deficits in executive functions and memory. The severity of these deficits varied inter-individually. Patients with early immunotherapy performed significantly better. The most severe deficits were observed with inefficient or delayed initial treatment. Our results suggest that cognitive deficits constitute a major long-term morbidity of anti-NMDAR encephalitis. These deficits relate to the distribution of NMDARs in the human brain and their functional role in normal cognition. Good cognitive long-term outcome may depend on early and aggressive treatment.
登录
查看更多内容
DOI：
10.1093/brain/awq113
发表时间：
2010-06
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Irani SR;Bera K;Waters P;Zuliani L;Maxwell S;Zandi MS;Friese MA;Galea I;Kullmann DM;Beeson D;Lang B;Bien CG;Vincent A
通讯作者：
Vincent A
影响因子：
48
作者：
Dalmau, Josep;Gleichman, Amy J.;Hughes, Ethen G.;Rossi, Jeffrey E.;Peng, Xiaoyu;Lai, Meizan;Dessain, Scott K.;Rosenfeld, Mynna R.;Balice-Gordon, Rita;Lynch, David R.
通讯作者：
Lynch, David R.
影响因子：
64.5
作者：
Tsien, JZ;Huerta, PT;Tonegawa, S
通讯作者：
Tonegawa, S
影响因子：
9.9
作者：
Pruess, H.;Dalmau, J.;Wandinger, K. P.
通讯作者：
Wandinger, K. P.
影响因子：
8.9
作者：
Flanagan, Eoin P.;McKeon, Andrew;Pittock, Sean J.
通讯作者：
Pittock, Sean J.