Endocrine Role of the Renin-Angiotensin System in Human Adipose Tissue and Muscle: Effect of &bgr;-Adrenergic Stimulation
Endocrine Role of the Renin-Angiotensin System in Human Adipose Tissue and Muscle: Effect of &bgr;-Adrenergic Stimulation
复制标题
肾素-血管紧张素系统在人体脂肪组织和肌肉中的内分泌作用：
作者：
G. Goossens;J. Jocken;E. Blaak;P. Schiffers;W. Saris;M. V. van Baak
The renin-angiotensin system has been implicated in obesity-related hypertension and insulin resistance. We examined whether locally produced components of the renin-angiotensin system in adipose tissue and skeletal muscle play an endocrine role in vivo in humans. Furthermore, the effects of &bgr;-adrenergic stimulation on plasma concentrations and tissue release of renin-angiotensin system components were investigated. Systemic renin-angiotensin system components and arteriovenous differences of angiotensin II (Ang II) and angiotensinogen (AGT) across abdominal subcutaneous adipose tissue and skeletal muscle were assessed in combination with measurements of tissue blood flow before and during systemic &bgr;-adrenergic stimulation in 13 lean and 10 obese subjects. Basal plasma Ang II and AGT concentrations were not significantly different between lean and obese subjects. Ang II concentrations were increased in obese compared with lean subjects during &bgr;-adrenergic stimulation (12.6±1.5 versus 8.1±1.0 pmol/L; P=0.04), whereas AGT concentrations remained unchanged. Plasma renin activity increased to a similar extent in lean and obese subjects during &bgr;-adrenergic stimulation (both P<0.01). No net Ang II release across adipose tissue and skeletal muscle could be detected in both groups of subjects. However, AGT was released from adipose tissue and muscle during &bgr;-adrenergic stimulation in obese subjects (both P<0.05). In conclusion, locally produced Ang II in adipose tissue and skeletal muscle exerts no endocrine role in lean and obese subjects. In contrast, AGT is released from adipose tissue and muscle in obese subjects during &bgr;-adrenergic stimulation, which may contribute to the increased plasma Ang II concentrations during &bgr;-adrenergic stimulation in obese subjects.
有证据表明β-肾上腺素能系统和前列腺素通过不同的机制刺激肾素释放。
DOI：
10.1210/jcem-61-3-399
发表时间：
1985
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Hsueh,WA;Goldstone,R;Carlson,EJ;Horton,R
通讯作者：
Horton,R
影响因子：
9.8
作者：
ABUMRAD, NN;RABIN, D;LACY, WW
通讯作者：
LACY, WW
人故意低血压期间肾素分泌和肾血流动力学的肾上腺素调节。
DOI：
10.1152/ajprenal.1993.265.5.f686
发表时间：
1993
期刊：
The American journal of physiology
影响因子：
--
作者：
Zayas,VM;Blumenfeld,JD;Bading,B;McDonald,M;James,GD;Lin,YF;Sharrock,NE;Sealey,JE;Laragh,JH
通讯作者：
Laragh,JH