Interstitial lung abnormalities in patients with stage I non-small cell lung cancer are associated with shorter overall survival: the Boston lung cancer study.
Interstitial lung abnormalities in patients with stage I non-small cell lung cancer are associated with shorter overall survival: the Boston lung cancer study.
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DOI：
10.1186/s40644-021-00383-w
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发表时间：
2021-01-19
期刊：
影响因子：
--
通讯作者：
Hatabu H
中科院分区：
文献类型：
--
作者：
Hida T;Hata A;Lu J;Valtchinov VI;Hino T;Nishino M;Honda H;Tomiyama N;Christiani DC;Hatabu H
间质性肺异常（ILA）可以在肺癌患者的计算机断层扫描（CT）中检测到，并与晚期非小细胞肺癌（NSCLC）患者的死亡率相关。本研究的目的是使用波士顿肺癌研究队列证明ILA对I期NSCLC患者死亡率的意义。在这项回顾性研究中，研究了2000年至2011年的231例I期NSCLC患者（中位年龄69岁; 93例男性，138例女性）。在治疗前使用3分量表（0 =无ILA证据，1 = ILA可疑，2 = ILA）通过序贯阅读方法对基线CT扫描进行ILA评分。ILA评分2被认为存在ILA。采用log-rank检验和多变量考克斯比例风险模型分析ILA评分、年龄、性别、吸烟状况和治疗等混杂变量对总生存期（OS）的影响。231例I期NSCLC患者中有22例（9.5%）存在ILA。ILA的存在与较短的OS相关（ILA评分2的患者，中位数3.85年[95%置信区间（CI）：3.36 -未达到（NR）]; ILA评分0或1的患者，中位数10.16年[95%CI：8.65 - NR]; P < 0.0001）。在考克斯比例风险模型中，在调整年龄、性别、吸烟和治疗后，ILA的存在对死亡风险的增加仍具有显著性（HR = 2.88，P = 0.005）。在9.5%的I期NSCLC患者的CT上检测到ILA。ILA的存在与较短的OS显著相关，并且可能是I期NSCLC中较短生存期的影像学标志物。在线版本包含补充材料，可通过10.1186/s40644-021-00383-w获得。
Interstitial lung abnormalities (ILA) can be detected on computed tomography (CT) in lung cancer patients and have an association with mortality in advanced non-small cell lung cancer (NSCLC) patients. The aim of this study is to demonstrate the significance of ILA for mortality in patients with stage I NSCLC using Boston Lung Cancer Study cohort. Two hundred and thirty-one patients with stage I NSCLC from 2000 to 2011 were investigated in this retrospective study (median age, 69 years; 93 males, 138 females). ILA was scored on baseline CT scans prior to treatment using a 3-point scale (0 = no evidence of ILA, 1 = equivocal for ILA, 2 = ILA) by a sequential reading method. ILA score 2 was considered the presence of ILA. The difference of overall survival (OS) for patients with different ILA scores were tested via log-rank test and multivariate Cox proportional hazards models were used to estimate hazard ratios (HRs) including ILA score, age, sex, smoking status, and treatment as the confounding variables. ILA was present in 22 out of 231 patients (9.5%) with stage I NSCLC. The presence of ILA was associated with shorter OS (patients with ILA score 2, median 3.85 years [95% confidence interval (CI): 3.36 – not reached (NR)]; patients with ILA score 0 or 1, median 10.16 years [95%CI: 8.65 - NR]; P < 0.0001). In a Cox proportional hazards model, the presence of ILA remained significant for increased risk for death (HR = 2.88, P = 0.005) after adjusting for age, sex, smoking and treatment. ILA was detected on CT in 9.5% of patients with stage I NSCLC. The presence of ILA was significantly associated with a shorter OS and could be an imaging marker of shorter survival in stage I NSCLC. The online version contains supplementary material available at 10.1186/s40644-021-00383-w.
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影响因子：
158.5
作者：
Lynch, TJ;Bell, DW;Haber, DA
通讯作者：
Haber, DA
影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
DOI：
10.1056/nejmoa1007285
发表时间：
2011-03-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Washko GR;Hunninghake GM;Fernandez IE;Nishino M;Okajima Y;Yamashiro T;Ross JC;Estépar RS;Lynch DA;Brehm JM;Andriole KP;Diaz AA;Khorasani R;D'Aco K;Sciurba FC;Silverman EK;Hatabu H;Rosas IO;COPDGene Investigators
通讯作者：
COPDGene Investigators
DOI：
10.1056/nejmoa1216076
发表时间：
2013-06-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hunninghake GM;Hatabu H;Okajima Y;Gao W;Dupuis J;Latourelle JC;Nishino M;Araki T;Zazueta OE;Kurugol S;Ross JC;San José Estépar R;Murphy E;Steele MP;Loyd JE;Schwarz MI;Fingerlin TE;Rosas IO;Washko GR;O'Connor GT;Schwartz DA
通讯作者：
Schwartz DA
影响因子：
4.6
作者：
Saito, Yuichi;Kawai, Yasuyuki;Hoshi, Eishin
通讯作者：
Hoshi, Eishin