Gluteofemoral adipose tissue plays a major role in production of the lipokine palmitoleate in humans.
Gluteofemoral adipose tissue plays a major role in production of the lipokine palmitoleate in humans.
复制标题
臀肌脂肪组织在人类的脂蛋白棕榈酸酯的生产中起着重要作用。
作者：
Pinnick KE;Neville MJ;Fielding BA;Frayn KN;Karpe F;Hodson L
下半身脂肪组织（AT）的扩张与心血管疾病和糖尿病风险的降低相矛盾。我们检查了下半身AT的有益代谢特性是否与胰岛素增敏脂因子棕榈酸酯（16：1 n-7）的产生和释放有关。使用静脉动脉差分采样，我们调查了16：1 n-7从下半身（臀股）和上身（腹部皮下）AT库的相对释放。分析成对的臀股和腹部皮下AT样本的甘油三酯脂肪酸组成和mRNA表达。最后，测定分离的人前脂肪细胞的甘油三酯脂肪酸组成。与腹部皮下AT相比，16：1 n-7的相对释放从臀股AT显著更高。硬脂酰辅酶A去饱和酶1（SCD 1），参与内源性16：1 n-7生产的关键酶，更高的表达在臀股AT，并与更大的富集16：1 n-7。此外，从臀股AT分离的人前脂肪细胞显示出更高含量的SCD 1衍生的脂肪酸。我们证明，人类臀股AT在确定脂因子棕榈油酸酯的全身浓度中起着重要作用。此外，这似乎是臀股AT的固有特征。我们认为，下半身AT的有益代谢特性可能部分解释了棕榈酸酯的内在更大的生产和释放。
The expansion of lower-body adipose tissue (AT) is paradoxically associated with reduced cardiovascular disease and diabetes risk. We examined whether the beneficial metabolic properties of lower-body AT are related to the production and release of the insulin-sensitizing lipokine palmitoleate (16:1n-7). Using venoarterial difference sampling, we investigated the relative release of 16:1n-7 from lower-body (gluteofemoral) and upper-body (abdominal subcutaneous) AT depots. Paired gluteofemoral and abdominal subcutaneous AT samples were analyzed for triglyceride fatty acid composition and mRNA expression. Finally, the triglyceride fatty acid composition of isolated human preadipocytes was determined. Relative release of 16:1n-7 was markedly higher from gluteofemoral AT compared with abdominal subcutaneous AT. Stearoyl-CoA desaturase 1 (SCD1), the key enzyme involved in endogenous 16:1n-7 production, was more highly expressed in gluteofemoral AT and was associated with greater enrichment of 16:1n-7. Furthermore, isolated human preadipocytes from gluteofemoral AT displayed a higher content of SCD1-derived fatty acids. We demonstrate that human gluteofemoral AT plays a major role in determining systemic concentrations of the lipokine palmitoleate. Moreover, this appears to be an inherent feature of gluteofemoral AT. We propose that the beneficial metabolic properties of lower-body AT may be partly explained by the intrinsically greater production and release of palmitoleate.
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影响因子：
64.5
作者：
Cao H;Gerhold K;Mayers JR;Wiest MM;Watkins SM;Hotamisligil GS
通讯作者：
Hotamisligil GS
血浆NEFA在餐后状态下的脂肪组织中存储：与性别有关的区域差异。
影响因子：
8.2
作者：
Koutsari, C.;Snozek, C. L. H.;Jensen, M. D.
通讯作者：
Jensen, M. D.
影响因子：
7.7
作者：
McQuaid SE;Hodson L;Neville MJ;Dennis AL;Cheeseman J;Humphreys SM;Ruge T;Gilbert M;Fielding BA;Frayn KN;Karpe F
通讯作者：
Karpe F
影响因子：
4.1
作者：
Dimopoulos, Nikolaos;Watson, Maria;Hundal, Harinder S.
通讯作者：
Hundal, Harinder S.
影响因子：
7.1
作者：
Mozaffarian, Dariush;Cao, Haiming;Hotamisligil, Gokhan S.
通讯作者：
Hotamisligil, Gokhan S.