Segregation and integration of the functional connectome in neurodevelopmentally 'at risk' children.
Segregation and integration of the functional connectome in neurodevelopmentally 'at risk' children.
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DOI：
10.1111/desc.13209
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发表时间：
2022-05
影响因子：
3.7
通讯作者：
Astle DE
中科院分区：
文献类型：
--
作者：
Jones JS;CALM Team;Astle DE
内在连接网络（ICN）内部和之间的功能连接在发育过程中发生变化，并被认为支持高阶认知功能。但是这个过程有多大的变化，它是否会随着认知发展的改变而变化？我们调查了神经发育“高危”儿童ICN内和ICN之间整合和隔离的年龄相关变化，这些儿童被从业者确定为在注意力、学习、语言或记忆方面存在认知困难。在我们的分析中，我们使用了10个认知任务的电池的性能，以及175名高危儿童和62名5-16岁的对照儿童的静息状态功能磁共振成像。我们观察到两个网络对之间的功能连接显着的年龄组的相互作用。在我们的比较样本中，相对于高危儿童，腹侧注意力和视觉网络之间的整合以及边缘系统和额顶叶网络的分离随着年龄的增长而增加。此外，腹侧注意力和视觉网络之间的功能连接在比较儿童显着介导的年龄相关的改善执行功能，相比，在风险儿童。我们的结论是，ICN之间的整合表现出不同的神经发育趋势，在广大的儿童群体经历认知困难，这些差异在功能性大脑组织可能部分解释了普遍的认知困难，在这个群体在童年和青春期。
Functional connectivity within and between Intrinsic Connectivity Networks (ICNs) transforms over development and is thought to support high order cognitive functions. But how variable is this process, and does it diverge with altered cognitive development? We investigated age-related changes in integration and segregation within and between ICNs in neurodevelopmentally ‘at-risk’ children, identified by practitioners as experiencing cognitive difficulties in attention, learning, language, or memory. In our analysis we used performance on a battery of 10 cognitive tasks, alongside resting-state functional Magnetic Resonance Imaging in 175 at-risk children and 62 comparison children aged 5-16. We observed significant age-by-group interactions in functional connectivity between two network pairs. Integration between the ventral attention and visual networks and segregation of the limbic and fronto-parietal networks increased with age in our comparison sample, relative to at-risk children. Furthermore, functional connectivity between the ventral attention and visual networks in comparison children significantly mediated age-related improvements in executive function, compared to at-risk children. We conclude that integration between ICNs show divergent neurodevelopmental trends in the broad population of children experiencing cognitive difficulties, and that these differences in functional brain organisation may partly explain the pervasive cognitive difficulties within this group over childhood and adolescence.
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影响因子：
3.7
作者：
Astle DE;Bathelt J;CALM Team;Holmes J
通讯作者：
Holmes J
DOI：
10.1016/j.bpsc.2017.10.005
发表时间：
2018-03
期刊：
Biological psychiatry. Cognitive neuroscience and neuroimaging
影响因子：
--
作者：
Cai W;Chen T;Szegletes L;Supekar K;Menon V
通讯作者：
Menon V
影响因子：
3.2
作者：
Chai XJ;Ofen N;Gabrieli JD;Whitfield-Gabrieli S
通讯作者：
Whitfield-Gabrieli S
DOI：
10.1016/j.jaac.2018.01.014
发表时间：
2018-04-01
影响因子：
13.3
作者：
Bathelt, Joe;Holmes, Joni;Astle, Duncan E.
通讯作者：
Astle, Duncan E.
影响因子：
16.2
作者：
Cui, Zaixu;Li, Hongming;Satterthwaite, Theodore D.
通讯作者：
Satterthwaite, Theodore D.