Selective development of anticorrelated networks in the intrinsic functional organization of the human brain.
Selective development of anticorrelated networks in the intrinsic functional organization of the human brain.
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DOI：
10.1162/jocn_a_00517
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发表时间：
2014-03
影响因子：
3.2
通讯作者：
Whitfield-Gabrieli S
中科院分区：
文献类型：
--
作者：
Chai XJ;Ofen N;Gabrieli JD;Whitfield-Gabrieli S
我们通过8-24岁的儿童、青少年和年轻人的静息态fMRI测量，检查了默认网络（对于需要注意力的任务，大脑区域通常会失活）内在功能连接的正常发展。我们调查了正相关和负相关，并采用分析方法，允许有效的解释负相关，也最大限度地减少了运动伪影的影响，往往混淆在发育神经影像。随着年龄的增长，有强大的发展增长的负相关性，包括内侧pFC（MPFC）和背外侧pFC（DLPFC）之间的和侧顶叶皮质和与背侧注意网络相关的脑区。在多个地区之间，这些相关性从儿童的正相关性逆转为成人的负相关性。在控制运动后，默认网络内正相关性的年龄相关变化低于统计阈值。在成人中，有证据表明MPFC和DLPFC之间更大的负相关性与上级认知表现相关，MPFC和DLPFC之间内在的负相关性的发展可能是从儿童期到青年期工作记忆和执行功能大幅增长的标志。
We examined the normal development of intrinsic functional connectivity of the default network (brain regions typically deactivated for attention-demanding tasks) as measured by resting-state fMRI in children, adolescents, and young adults ages 8–24 years. We investigated both positive and negative correlations and employed analysis methods that allowed for valid interpretation of negative correlations and that also minimized the influence of motion artifacts that are often confounds in developmental neuroimaging. As age increased, there were robust developmental increases in negative correlations, including those between medial pFC (MPFC) and dorsolateral pFC (DLPFC) and between lateral parietal cortices and brain regions associated with the dorsal attention network. Between multiple regions, these correlations reversed from being positive in children to negative in adults. Age-related changes in positive correlations within the default network were below statistical threshold after controlling for motion. Given evidence in adults that greater negative correlation between MPFC and DLPFC is associated with superior cognitive performance, the development of an intrinsic anticorrelation between MPFC and DLPFC may be a marker of the large growth of working memory and executive functions that occurs from childhood to young adulthood.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
DOI：
10.1073/pnas.0901831106
发表时间：
2009-06-23
影响因子：
11.1
作者：
Deco, Gustavo;Jirsa, Viktor;Koetter, Rolf
通讯作者：
Koetter, Rolf
影响因子：
3.7
作者：
Fransson, Peter;Aden, Ulrika;Lagercrantz, Hugo
通讯作者：
Lagercrantz, Hugo
影响因子：
4.8
作者：
Gao, Wei;Lin, Weili
通讯作者：
Lin, Weili