Sex differences in the functional and structural neuroanatomy of dental phobia
Sex differences in the functional and structural neuroanatomy of dental phobia
复制标题
牙科恐惧症功能和结构神经解剖学的性别差异
DOI：
10.1007/s00429-012-0428-z
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发表时间：
2013
影响因子：
3.1
通讯作者：
Schäfer
中科院分区：
文献类型：
--
作者：
Schienle;Scharmüller;Leutgeb;Schäfer
虽然牙科恐惧症是一种常见的精神障碍，男性和女性都会受到影响，但人们对神经层面的性别差异知之甚少。患有牙科恐惧症的患者(20名男性，25名女性)和健康对照组(18名男性，23名女性)参加了功能磁共振成像(FMRI)实验。向他们展示了描述牙科治疗的图片，这些图片通常会引发恐惧、厌恶和中性的内容。在功能磁共振实验之后，参与者对图片的情感价值进行了评分。此外，对患者和对照组之间以及性别之间的灰质体积(GMV)进行了比较。男性和女性患者对照片的反应不同。女性表现出更大的尾状核激活，而男性表现出更强的背外侧前额叶皮质(DLPFC)受累。他们的DLPFC激活与经验性唤醒呈负相关。牙齿恐惧症女性的特征是尾状体积比恐惧症男性更大。该结构的GMV与暴露时的唤醒和症状严重程度呈正相关，仅在女性患者中如此。这项研究首次提供了患有牙科恐惧症患者特定性别的大脑激活和结构的证据。症状激发时的神经模式以及大脑结构的特异性可能反映了两性注意和自我控制策略的不同。考虑到这些差异可能有助于更有效地治疗牙科恐惧症。
Although dental phobia is a common mental disorder, which afflicts both men and women, little is known about sex differences at the neural level. Patients suffering from dental phobia (20 men, 25 women) and healthy controls (18 men, 23 women) participated in a functional magnetic resonance imaging (fMRI) experiment. They were shown pictures depicting dental treatment, generally fear-eliciting, disgust-eliciting and neutral contents. After the fMRI experiment, the participants rated the affective value of the pictures. Additionally, grey matter volume (GMV) was compared between patients and controls, as well as between the sexes. Male and female patients responded differently to the phobogenic pictures. Women showed greater activation of the caudate nucleus, whereas men exhibited enhanced dorsolateral prefrontal cortex (DLPFC) involvement. Their DLPFC activation was negatively correlated with experienced arousal. Dentophobic females were characterized by a greater caudate volume relative to phobic males. The GMV of this structure was positively correlated with experienced arousal during exposure and symptom severity, only in female patients. This study provides first evidence of sex-specific brain activation and structure in patients suffering from dental phobia. The neural pattern during symptom provocation as well as the brain structural specificity might mirror different attention and self-control strategies of both sexes. The consideration of such differences could contribute to greater effectiveness in treating dental phobia.
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作者：
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作者：
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