Preeclampsia-Associated lncRNA INHBA-AS1 Regulates the Proliferation, Invasion, and Migration of Placental Trophoblast Cells.
Preeclampsia-Associated lncRNA INHBA-AS1 Regulates the Proliferation, Invasion, and Migration of Placental Trophoblast Cells.
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先兆子痫相关 lncRNA INHBA-AS1 调节胎盘滋养层细胞的增殖、侵袭和迁移
DOI：
10.1016/j.omtn.2020.09.033
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发表时间：
2020-12-04
期刊：
影响因子：
--
通讯作者：
Yang X
中科院分区：
文献类型：
--
作者：
Jiang S;Chen Q;Liu H;Gao Y;Yang X;Ren Z;Gao Y;Xiao L;Zhong M;Yu Y;Yang X
先兆子痫被认为是由胎盘形成受损和滋养层浸润不足引起的，导致子宫螺旋动脉重塑和血管生成受损。然而，潜在的分子机制仍然未知。我们最近进行了胎盘长非编码RNA（lncRNA）的转录组分析，并确定了383个早发性重度子痫前期差异表达的lncRNA。在这里，我们报告我们的鉴定lncRNA INHBA-AS 1作为先兆子痫及其下游途径，可能参与胎盘形成的潜在致病因素。我们发现INHBA-AS 1在患者中上调，并与临床严重程度呈正相关。我们在数据库中系统地搜索了潜在的INHBA-AS 1结合转录因子及其靶点，发现这些靶点富含患者胎盘中差异表达的基因。我们进一步证明INHBA-AS 1通过抑制转录因子CENPB与TNF受体相关因子1（TRAF 1）启动子的结合来抑制滋养层细胞的侵袭和迁移。因此，我们已经确定了失调的途径“INHBA-AS 1-CENPB-TRAF 1”通过抑制胎盘形成期间滋养层细胞的增殖、侵袭和迁移而作为先兆子痫发病机制的贡献者。先兆子痫被认为是由胎盘形成受损引起的。Xinping Yang及其同事报道了lncRNA INHBA-AS 1作为先兆子痫的潜在致病因素的鉴定。他们发现INHBA-AS 1与临床严重程度正相关，并通过抑制滋养层细胞的侵袭和迁移参与发病机制。
Preeclampsia is believed to be caused by impaired placentation with insufficient trophoblast invasion, leading to impaired uterine spiral artery remodeling and angiogenesis. However, the underlying molecular mechanism remains unknown. We recently carried out transcriptome profiling of placental long noncoding RNAs (lncRNAs) and identified 383 differentially expressed lncRNAs in early-onset severe preeclampsia. Here, we are reporting our identification of lncRNA INHBA-AS1 as a potential causal factor of preeclampsia and its downstream pathways that may be involved in placentation. We found that INHBA-AS1 was upregulated in patients and positively correlated with clinical severity. We systematically searched for potential INHBA-AS1-binding transcription factors and their targets in databases and found that the targets were enriched with differentially expressed genes in the placentae of patients. We further demonstrated that the lncRNA INHBA-AS1 inhibited the invasion and migration of trophoblast cells through restraining the transcription factor CENPB from binding to the promoter of TNF receptor-associated factor 1 (TRAF1). Therefore, we have identified the dysregulated pathway “INHBA-AS1-CENPB-TRAF1” as a contributor to the pathogenesis of preeclampsia through prohibiting the proliferation, invasion, and migration of trophoblasts during placentation. Preeclampsia is believed to be caused by impaired placentation. Xinping Yang and colleagues report the identification of lncRNA INHBA-AS1 as a potential causal factor of preeclampsia. They found that INHBA-AS1 is positively correlated with clinical severity and involved in the pathogenesis through inhibiting the invasion and migration of trophoblast cells.
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DOI：
10.1038/nrneph.2014.102
发表时间：
2014-08
期刊：
Nature reviews. Nephrology
影响因子：
--
作者：
Chaiworapongsa T;Chaemsaithong P;Yeo L;Romero R
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Romero R
DOI：
10.1016/j.bbcan.2015.07.001
发表时间：
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Biochimica et biophysica acta
影响因子：
--
作者：
Bhan A;Mandal SS
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Mandal SS
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9.8
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Laivuori, H;Lahermo, P;Kere, J
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Kere, J
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Jimenez, Lizandra;Lim, Jihyeon;Segall, Jeffrey E.
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Segall, Jeffrey E.
DOI：
10.1136/bmj.f6564
发表时间：
2013-11-07
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Ananth CV;Keyes KM;Wapner RJ
通讯作者：
Wapner RJ