"A sense of the bigger picture:" A qualitative analysis of follow-up interviews with people with bipolar disorder who self-reported psilocybin use.
"A sense of the bigger picture:" A qualitative analysis of follow-up interviews with people with bipolar disorder who self-reported psilocybin use.
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DOI：
10.1371/journal.pone.0279073
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Michalak, Erin
中科院分区：
文献类型：
--
作者：
DellaCrosse, Meghan;Pleet, Mollie;Morton, Emma;Ashtari, Amir;Sakai, Kimberly;Woolley, Josh;Michalak, Erin
双相情感障碍（BD）患者抑郁的时间比躁狂/轻躁狂患者多，抑郁症与心理社会功能和生活质量的损害比躁狂/轻躁狂患者更大。新出现的证据表明，“神奇蘑菇”中的精神活性化合物裸盖菇素是一种很有希望的治疗单相抑郁症的药物。裸盖菇素治疗的临床试验排除了BD患者，以预防可能的不良反应（例如，躁狂症）。我们的研究集中于食用含裸盖菇素蘑菇的BD成年人的经历，旨在（1）了解其对BD症状的主观影响，（2）加深对I期调查结果的理解，（3）阐明与自然环境中不良反应相关的特定背景因素。在一项国际调查（第一阶段）之后，对15名受访者进行了后续访谈（第二阶段），以进一步了解BD成人中的裸盖菇素使用情况。作为一个更大的混合方法解释序贯设计研究的一部分，自反性主题分析被用来阐述研究结果。制定了三个包含分主题的主题。(1)改善心理健康：（1.1）降低抑郁的影响和严重程度，（1.2）增加情绪处理，（1.3）发展新的观点，（1.4）更好的放松和睡眠。(2)非预期的心理健康影响：（2.1）睡眠变化，（2.2）躁狂严重程度增加，（2.3）住院治疗，（2.4）令人痛苦的感官体验。(3)使用裸盖菇素的显著背景因素包括：（3.1）多种物质使用和裸盖菇素剂量，（3.2）单独与社会经验，（3.3）裸盖菇素前睡眠剥夺。我们的研究结果证明了在这一人群中使用裸盖菇素的益处和风险。精心设计的临床试验，重点是安全性和初步疗效是必要的。
People with bipolar disorder (BD) spend more time depressed than manic/hypomanic, and depression is associated with greater impairments in psychosocial functioning and quality of life than mania/hypomania. Emerging evidence suggests psilocybin, the psychoactive compound in “magic mushrooms,” is a promising treatment for unipolar depression. Clinical trials of psilocybin therapy have excluded people with BD as a precaution against possible adverse effects (e.g., mania). Our study centered the experiences of adults living with BD who consumed psilocybin-containing mushrooms, and aimed to (1) understand its subjective impacts on BD symptoms, (2) deepen understanding of Phase I survey results, and (3) elucidate specific contextual factors associated with adverse reactions in naturalistic settings. Following an international survey (Phase I), follow-up interviews were conducted with 15 respondents (Phase II) to further understand psilocybin use among adults with BD. As part of a larger mixed-methods explanatory sequential design study, reflexive thematic analysis was used to elaborate findings. Three major themes containing sub-themes were developed. (1) Mental Health Improvements: (1.1) decreased impact and severity of depression, (1.2) increased emotion processing, (1.3) development of new perspectives, and (1.4) greater relaxation and sleep. (2) Undesired Mental Health Impacts: (2.1) changes in sleep, (2.2) increased mania severity, (2.3) hospitalization, and (2.4) distressing sensory experiences. (3) Salient Contextual Factors for psilocybin use included: (3.1) poly-substance use and psilocybin dose, (3.2) solo versus social experiences, and (3.3) pre-psilocybin sleep deprivation. Our findings demonstrate both benefits and risks of psilocybin use in this population. Carefully designed clinical trials focused on safety and preliminary efficacy are warranted.
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影响因子：
25.8
作者：
Davis AK;Barrett FS;May DG;Cosimano MP;Sepeda ND;Johnson MW;Finan PH;Griffiths RR
通讯作者：
Griffiths RR
影响因子：
4.1
作者：
Carhart-Harris, Robin L.;Roseman, Leor;Kaelen, Mendel
通讯作者：
Kaelen, Mendel
影响因子：
5.4
作者：
Adida, Marc;Clark, Luke;Goodwin, Guy M.
通讯作者：
Goodwin, Guy M.
影响因子：
3.4
作者：
Carhart-Harris RL;Bolstridge M;Day CMJ;Rucker J;Watts R;Erritzoe DE;Kaelen M;Giribaldi B;Bloomfield M;Pilling S;Rickard JA;Forbes B;Feilding A;Taylor D;Curran HV;Nutt DJ
通讯作者：
Nutt DJ
影响因子：
1.7
作者：
Agin-Liebes, Gabrielle;Ekman, Eve;Woolley, Josh
通讯作者：
Woolley, Josh