Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles.
Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles.
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中枢神经系统损伤中小胶质细胞作用的神经生物学：受体介导的信号传导机制和功能作用
DOI：
10.1016/j.pneurobio.2014.06.002
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发表时间：
2014-08
影响因子：
6.7
通讯作者：
Chen, Jun
中科院分区：
文献类型：
--
作者：
Hu, Xiaoming;Liou, Anthony K. F.;Leak, Rehana K.;Xu, Mingyue;An, Chengrui;Suenaga, Jun;Shi, Yejie;Gao, Yanqin;Zheng, Ping;Chen, Jun
小胶质细胞是中枢神经系统（CNS）损伤和疾病的第一道免疫防御。这些高度可塑性的细胞在神经元损伤和恢复中起着双重作用，并且以其呈现不同表型的能力而闻名。广泛的表面受体在小胶质细胞上表达，并介导小胶质细胞对来自其他宿主细胞以及入侵微生物的信号的“开”或“关”反应。这些受体的整合作用导致严格调节的生物学功能，包括细胞移动性、吞噬作用、获得性免疫的诱导和营养因子/炎症介质释放。在过去的几年中，已经取得了重大进展，破译与这些受体及其特定的细胞功能相关的信号传导机制。在这篇综述中，我们描述了目前的知识状态的表面受体参与小胶质细胞活化，强调他们的参与不同的功能程序和他们在中枢神经系统损伤中的作用。从这次审查中可以明显看出，小胶质细胞的稳态是通过多种平衡策略精心维持的，包括但不限于“开”和“关”受体信号传导。这些小胶质细胞受体的特异性调控可能是一个有前途的治疗策略，对中枢神经系统损伤。
Microglia are the first line of immune defense against central nervous system (CNS) injuries and disorders. These highly plastic cells play dualistic roles in neuronal injury and recovery and are known for their ability to assume diverse phenotypes. A broad range of surface receptors are expressed on microglia and mediate microglial ‘On’ or ‘Off’ responses to signals from other host cells as well as invading microorganisms. The integrated actions of these receptors result in tightly regulated biological functions, including cell mobility, phagocytosis, the induction of acquired immunity, and trophic factor/inflammatory mediator release. Over the last few years, significant advances have been made towards deciphering the signaling mechanisms related to these receptors and their specific cellular functions. In this review, we describe the current state of knowledge of the surface receptors involved in microglial activation, with an emphasis on their engagement of distinct functional programs and their roles in CNS injuries. It will become evident from this review that microglial homeostasis is carefully maintained by multiple counterbalanced strategies, including, but not limited to, ‘On’ and ‘Off’ receptor signaling. Specific regulation of theses microglial receptors may be a promising therapeutic strategy against CNS injuries.
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影响因子：
16.2
作者：
Bhaskar, Kiran;Konerth, Megan;Kokiko-Cochran, Olga N.;Cardona, Astrid;Ransohoff, Richard M.;Lamb, Bruce T.
通讯作者：
Lamb, Bruce T.
影响因子：
4.7
作者：
Banisadr, G;Quéraud-Lesaux, F;Parsadaniantz, SM
通讯作者：
Parsadaniantz, SM
影响因子：
6.2
作者：
Biber, K;Sauter, A;Boddeke, HWGM
通讯作者：
Boddeke, HWGM
影响因子：
3.3
作者：
Biber, K;Dijkstra, I;Boddeke, HWGM
通讯作者：
Boddeke, HWGM
影响因子：
5.5
作者：
Bianchi, Roberta;Adami, Cecilia;Donato, Rosario
通讯作者：
Donato, Rosario