Applications of optical coherence tomography in cardiovascular medicine, Part 2.
Applications of optical coherence tomography in cardiovascular medicine, Part 2.
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DOI：
10.1007/s12350-009-9100-2
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发表时间：
2009-07
影响因子：
2.4
通讯作者：
Feldman, Marc D.
中科院分区：
文献类型：
--
作者：
Villard, Joseph W.;Paranjape, Amit S.;Victor, Danielle A.;Feldman, Marc D.
Despite the concerns raised by a well-publicized presentation at the World Congress of Cardiology (WCC) meeting in September 2006, 1 Drug Eluting Stents (DES) have approximately the same short-term and long-term safety profile as Bare Metal Stents (BMS) when used for FDA-labeled indications. 2-5 DES have an in-stent thrombosis rate of 3.6% within 4 years 6 compared to a 3.3% rate for BMS. The main disadvantage of DES is the rate of late complications, specifically stent thrombosis. 4 This usually occurs after the first year and is usually associated with discontinuation of antiplatelet therapy. 7, 8 The main benefit of DES is the decreased need for target vessel revascularization, 4 which is enough to be of a clinical advantage in recommending the continued use of DES. 9 However, there are still some issues that remain to be resolved with DES. The ideal amount of anti-proliferative drug and polymer which strikes the ideal balance between excess neointima formation and restenosis as one extreme, and permanent uncovered struts at the other extreme, has yet to be determined. The duration of antiplatelet therapy needed to minimize late stent thrombosis is still uncertain. Also, the extent to which resistance to aspirin and clopidogrel causes increased thrombosis requires further study. The effects of increased local drug dose due to overlapping stents are still unknown. Finally, the ideal polymer, be it hydrophilic or hydrophobic, which avoids local hypersensitivity reactions in patients have not yet been characterized.With OCT, clinicians now have an imaging tool that has the resolution and frame rate to study these issues in vivo in patients, rather than only at autopsy. And since OCT presents significantly enhanced resolution compared to IVUS, it is anticipated that OCT will aid in answering these unresolved issues related to DES.
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影响因子：
2.3
作者：
Cilingiroglu, Mehmet;Oh, Jung Hwan;Feldman, Marc D.
通讯作者：
Feldman, Marc D.
影响因子：
19.7
作者：
Ferencik, Maros;Chan, Raymond C.;Brady, Thomas J.
通讯作者：
Brady, Thomas J.
影响因子：
37.8
作者：
Finn, AV;Kolodgie, FD;Virmani, R
通讯作者：
Virmani, R
影响因子：
37.8
作者：
Costa, MA;Sabaté, M;Serruys, PW
通讯作者：
Serruys, PW
影响因子：
24
作者：
Ellis, Stephen G.;Colombo, Antonio;Stone, Gregg W.
通讯作者：
Stone, Gregg W.