The role of transcavitary ultrasonography in diagnosis and staging of nonmuscle-ınvasive bladder cancer: a prospective non-randomized clinical study.

The role of transcavitary ultrasonography in diagnosis and staging of nonmuscle-ınvasive bladder cancer: a prospective non-randomized clinical study.
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DOI:
10.1186/2193-1801-3-519
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发表时间:
2014
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影响因子:
--
通讯作者:
Unluer E
Unluer E
中科院分区:
其他
文献类型:
--
作者:
Oktem GC;Kocaaslan R;Karadag MA;Bagcioglu M;Demir A;Cecen K;Unluer E

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评估膀胱镜检查、计算机断层扫描 (CT)、经腔超声 (TCUS) 和细胞学单独或联合使用对浅表性膀胱癌诊断和评估的效果。对 1548 名患者进行了初次膀胱镜检查和冲洗细胞学检查。其中,206 名已证实患有膀胱肿瘤的患者被纳入这项前瞻性研究。在不知道膀胱镜检查结果的情况下,对膀胱肿瘤患者进行了 CT 和 TCUS。根据多样性和大小,病变被分为低风险(pTa)和高风险(pT1)浅表肿瘤。根据膀胱镜评估的肿瘤大小,患者被分为三类:≤1 cm(88 名患者,42.7%)、1-3 cm(51 名患者,24.8%)和≥3 cm(67 名患者,32.5%)。 TCUS 确定了 46 名(22.3%)有/无侵袭的高风险患者和 160 名(77.7%)无侵袭的低风险患者。总体而言,TCUS对肿瘤检测的敏感性、特异性、阳性预测值和阴性预测值分别为77.4%、60%、94.7%和22.2%。膀胱镜检查仍然是诊断膀胱癌最广泛使用的技术。 CT、TCUS 和细胞学联合使用可检测到 72% 经膀胱镜证实的肿瘤。在这三者中,TCUS 结果与膀胱镜检查结果的相关性最强。
To evaluate the efficacy of cystoscopy, computed tomography (CT), transcavitary ultrasound (TCUS) and cytology, separately and in combination, for the diagnosis and evaluation of superficial bladder cancer. Initial cystoscopy and wash-out cytology were performed for 1548 patients. Of these, 206 with proven bladder tumors were included in this prospective study. CT and TCUS were performed for patients with bladder tumors without knowledge of their cystoscopy results. The lesions were classified as low- (pTa) and high- (pT1) risk superficial tumors according to multiplicity and size. Patients were divided into three categories according to their cystoscopically evaluated tumor size: ≤1 cm (88 patients, 42.7%), 1–3 cm (51 patients, 24.8%) and ≥3 cm (67 patients, 32.5%). TCUS identified 46 (22.3%) high-risk patients with/without invasion and 160 (77.7%) low-risk patients with no invasion. Overall, the sensitivity, specificity, positive predictive value and negative predictive value of TCUS for tumor detection were 77.4%, 60%, 94.7% and 22.2%, respectively. Cystoscopy remains the most widely used technique for the diagnosis of bladder cancer. The combined use of CT, TCUS and cytology detected 72% of cystoscopically proven tumors. Among the three, TCUS findings exhibited the strongest correlation with cystoscopy findings.
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