Validity of cognitive screens for HIV-associated neurocognitive disorder: a systematic review and an informed screen selection guide.
Validity of cognitive screens for HIV-associated neurocognitive disorder: a systematic review and an informed screen selection guide.
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DOI：
10.1007/s11904-013-0176-6
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发表时间：
2013-12
影响因子：
4.6
通讯作者：
Brew, Bruce J.
中科院分区：
文献类型：
--
作者：
Kamminga, Jody;Cysique, Lucette A.;Lu, Grace;Batchelor, Jennifer;Brew, Bruce J.
关键词：
已经提出了各种筛查工具来识别HIV相关的神经认知障碍（HAND）。然而，与金标准神经心理学测试相比，还没有系统地评价它们在检测HAND方面的优势和劣势。使用标准检索程序检索了在联合抗逆转录病毒治疗时代进行的35项评估HAND筛查的研究。其中，19人（54%）将他们的屏幕与标准神经心理学测试进行了比较。研究的特征是标准有效性的广泛变化，主要是由于神经认知障碍的非标准定义，以及样本的人口统计学和临床异质性。缺乏对结构效度的评估，纵向可用性也没有建立。为了解决这些局限性，目前的审查提出了一个最敏感和具体的研究（> 70%）的总结，以及提供明确的警告，他们的弱点，并建议他们在艾滋病毒初级保健环境中使用。本文的在线版本（doi：10.1007/s11904-013-0176-6）包含补充材料，可供授权用户使用。
Various screening tools have been proposed to identify HIV-Associated Neurocognitive Disorder (HAND). However, there has been no systematic review of their strengths and weaknesses in detecting HAND when compared to gold standard neuropsychological testing. Thirty-five studies assessing HAND screens that were conducted in the era of combination antiretroviral therapy were retrieved using standard search procedures. Of those, 19 (54 %) compared their screen to standard neuropsychological testing. Studies were characterised by a wide variation in criterion validity primarily due to non-standard definition of neurocognitive impairment, and to the demographic and clinical heterogeneity of samples. Assessment of construct validity was lacking, and longitudinal useability was not established. To address these limitations, the current review proposed a summary of the most sensitive and specific studies (>70 %), as well as providing explicit caution regarding their weaknesses, and recommendations for their use in HIV primary care settings. The online version of this article (doi:10.1007/s11904-013-0176-6) contains supplementary material, which is available to authorized users.
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