Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection.
Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection.
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DOI：
10.1111/j.1574-6976.2012.00339.x
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发表时间：
2012-05
影响因子：
11.3
通讯作者：
Hultgren SJ
中科院分区：
文献类型：
--
作者：
Hannan TJ;Totsika M;Mansfield KJ;Moore KH;Schembri MA;Hultgren SJ
膀胱感染每年影响数以百万计的人，反复出现的症状性感染(膀胱炎)非常常见。由多药耐药尿路病原体引起的感染迅速增加，有可能使复发性膀胱炎成为一个日益令人担忧的公共卫生问题。尿路致病性大肠杆菌(UPEC)引起的膀胱感染占绝大多数。一旦进入下尿路，UPEC就面临着定居障碍，这构成了种群瓶颈，减少了多样性，并选择了合适的克隆。膀胱感染的一个关键的粘膜屏障是上皮(尿路上皮)。当UPEC侵入尿路上皮细胞并形成细胞内细菌群落(IBCs)时，它们会绕过这一屏障，这一过程需要1型菌毛。IBCS本质上是暂时性的，主要发生在急性感染期间。慢性膀胱感染很常见，既可以是潜伏性的，表现为静止性细胞内蓄积物(QIR)，也可以是活动性的，表现为无症状菌尿(ASB/ABU)或慢性膀胱炎。在小鼠中，膀胱感染的命运：QIR，ASB，或慢性膀胱炎，在感染的第一个24小时内确定，并构成一个假定的宿主-病原体粘膜检查点，有助于易感复发性膀胱炎。了解这些检查点和瓶颈对于我们了解膀胱感染和努力设计新的治疗策略至关重要。
Bladder infections affect millions of people yearly, and recurrent symptomatic infections (cystitis) are very common. The rapid increase in infections caused by multi-drug resistant uropathogens threatens to make recurrent cystitis an increasingly troubling public health concern. Uropathogenic E. coli (UPEC) cause the vast majority of bladder infections. Upon entry into the lower urinary tract, UPEC face obstacles to colonization that constitute population bottlenecks, reducing diversity and selecting for fit clones. A critical mucosal barrier to bladder infection is the epithelium (urothelium). UPEC bypass this barrier when they invade urothelial cells and form intracellular bacterial communities (IBCs), a process which requires type 1 pili. IBCs are transient in nature, occurring primarily during acute infection. Chronic bladder infection is common and can be either latent, in the form of the Quiescent Intracellular Reservoir (QIR), or active, in the form of asymptomatic bacteriuria (ASB/ABU) or chronic cystitis. In mice, the fate of bladder infection: QIR, ASB, or chronic cystitis, is determined within the first 24 hours of infection and constitutes a putative host-pathogen mucosal checkpoint that contributes to susceptibility to recurrent cystitis. Knowledge of these checkpoints and bottlenecks is critical for our understanding of bladder infection and efforts to devise novel therapeutic strategies.
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影响因子：
3.1
作者：
Billips, Benjamin K.;Schaeffer, Anthony J.;Klumpp, David J.
通讯作者：
Klumpp, David J.
影响因子：
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作者：
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DOI：
10.1073/pnas.96.9.5095
发表时间：
1999-04-27
影响因子：
11.1
作者：
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通讯作者：
Real, LA
影响因子：
4.4
作者：
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通讯作者：
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