Brain activity associated with quadriceps strength deficits after anterior cruciate ligament reconstruction.
Brain activity associated with quadriceps strength deficits after anterior cruciate ligament reconstruction.
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DOI：
10.1038/s41598-023-34260-2
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发表时间：
2023-05-17
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
前交叉韧带重建（ACL-R）后长期治疗抵抗性股四头肌无力会导致再损伤风险、患者结局不良和骨关节炎早期发展。损伤后无力的起源部分是神经学性质的，但尚不清楚局部脑活动是否与四头肌无力的临床指标相关。因此，本研究的目的是通过评估以股四头肌为主的膝关节任务（单侧膝关节从45°到0°屈曲/伸展的重复循环）的大脑活动与ACL-R后恢复活动的个体的力量不对称之间的关系，更好地了解损伤后股四头肌无力的神经贡献。招募了44名参与者（22名接受单侧ACL重建; 22名对照），并在60°/s下评估峰值等速膝关节伸肌扭矩，以计算股四头肌肢体对称指数（Q-LSI，受累/未受累肢体的比率）。相关性用于确定关键感觉运动脑区域内的平均%信号变化与Q-LSI的关系。还根据临床推荐的强度（Q-LSI <90%，n = 12; Q-LSI ≥ 90%，n = 10;对照组，所有n = 22，Q-LSI ≥ 90%）分组评价脑活动。较低的Q-LSI与对侧运动前皮层和舌回的活动增加有关（p <0.05）。与符合临床推荐Q-LSI ≥ 90的患者和健康对照组相比，不符合临床推荐强度的患者表现出更大的舌回活动（p < 0.05）。不对称性弱ACL-R患者显示更大的皮质活动比患者没有潜在的不对称性和健康对照组。
Prolonged treatment resistant quadriceps weakness after anterior cruciate ligament reconstruction (ACL-R) contributes to re-injury risk, poor patient outcomes, and earlier development of osteoarthritis. The origin of post-injury weakness is in part neurological in nature, but it is unknown whether regional brain activity is related to clinical metrics of quadriceps weakness. Thus, the purpose of this investigation was to better understand the neural contributions to quadriceps weakness after injury by evaluating the relationship between brain activity for a quadriceps-dominated knee task (repeated cycles of unilateral knee flexion/extension from 45° to 0°), , and strength asymmetry in individuals returned to activity after ACL-R. Forty-four participants were recruited (22 with unilateral ACL reconstruction; 22 controls) and peak isokinetic knee extensor torque was assessed at 60°/s to calculate quadriceps limb symmetry index (Q-LSI, ratio of involved/uninvolved limb). Correlations were used to determine the relationship of mean % signal change within key sensorimotor brain regions and Q-LSI. Brain activity was also evaluated group wise based on clinical recommendations for strength (Q-LSI < 90%, n = 12; Q-LSI ≥ 90%, n = 10; controls, all n = 22 Q-LSI ≥ 90%). Lower Q-LSI was related to increased activity in the contralateral premotor cortex and lingual gyrus (p < .05). Those who did not meet clinical recommendations for strength demonstrated greater lingual gyrus activity compared to those who met clinical recommendations Q-LSI ≥ 90 and healthy controls (p < 0.05). Asymmetrically weak ACL-R patients displayed greater cortical activity than patients with no underlying asymmetry and healthy controls.
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DOI：
10.5435/00124635-201009000-00003
发表时间：
2010-09
期刊：
The Journal of the American Academy of Orthopaedic Surgeons
影响因子：
--
作者：
Boden BP;Sheehan FT;Torg JS;Hewett TE
通讯作者：
Hewett TE
影响因子：
4.8
作者：
Cramer, SC;Weisskoff, RM;Rosen, BR
通讯作者：
Rosen, BR
影响因子：
5.7
作者：
Beckmann, CF;Jenkinson, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
3.8
作者：
Del Percio, Claudio;Babiloni, Claudio;Eusebi, Fabrizio
通讯作者：
Eusebi, Fabrizio
影响因子：
2.8
作者：
Chaput, Meredith;Onate, James A.;Grooms, Dustin R.
通讯作者：
Grooms, Dustin R.