Reduced graft-versus-host disease in C3-deficient mice is associated with decreased donor Th1/Th17 differentiation.
Reduced graft-versus-host disease in C3-deficient mice is associated with decreased donor Th1/Th17 differentiation.
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DOI：
10.1016/j.bbmt.2012.05.014
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发表时间：
2012-08
影响因子：
4.3
通讯作者：
Afshar-Kharghan, Vahid
中科院分区：
文献类型：
--
作者：
Ma, Qing;Li, Dan;Nurieva, Roza;Patenia, Rebecca;Bassett, Roland;Cao, Wei;Alekseev, Andrei M.;He, Hong;Molldrem, Jeffrey J.;Kroll, Michael H.;Champlin, Richard E.;Sale, George E.;Afshar-Kharghan, Vahid
异基因造血干细胞移植（allo-HSCT）后的移植物抗宿主病（GVHD）是由受体树突状细胞（DC）的激活和随后供体T细胞的增殖介导的。近年来研究表明，补体系统通过与淋巴细胞的相互作用来调节获得性免疫。补体蛋白参与DC的活化、向T细胞的抗原呈递和T细胞的增殖。我们在小鼠骨髓移植（BMT）模型上的研究表明，补体系统在GVHD中调节同种免疫反应。与野生型（WT）受体小鼠相比，补体系统中心成分（C3−/−）缺陷的小鼠具有显著较低的GVHD相关死亡率和发病率。在C3−/−受体的次级淋巴器官中，包括IFNγ+、IL 17+和IL 17 +IFNγ+亚群在内的供体来源的T细胞数量减少。此外，淋巴器官中受体CD 8 α+ CD 11 c+减少。我们的结论是C3调节Th 1/17分化的BMT，并定义了一个新的功能的补体系统在GVHD。
Graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is mediated by the activation of recipient dendritic cells (DCs) and subsequent proliferation of donor T cells. Recently complement system has been shown to modulate adaptive immunity through the interaction between the complement system and lymphocytes. Complement proteins participate in the activation of DCs, antigen presentation to T cells, and proliferation of T cells. Our studies with a murine model of bone marrow transplantation (BMT) demonstrate that complement system regulates alloimmune responses in GVHD. Mice deficient in the central component of the complement system (C3−/−) had significantly lower GVHD-related mortality and morbidity compared to the wild type (WT) recipient mice. The number of donor-derived T cells including IFNγ+, IL17+ and IL17+IFNγ+ subsets was decreased in secondary lymphoid organs of C3−/− recipients. Furthermore, there was a reduction of recipient CD8α+CD11c+ in lymphoid organs. We conclude C3 regulates Th1/17 differentiation in BMT, and define a novel function of the complement system in GVHD.
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影响因子：
32.4
作者：
Nurieva, Roza I.;Chung, Yeonseok;Hwang, Daehee;Yang, Xuexian O.;Kang, Hong Soon;Ma, Li;Wang, Yi-Hong;Watowich, Stephanie S.;Jetten, Anton M.;Tian, Qiang;Dong, Chen
通讯作者：
Dong, Chen
影响因子：
15.9
作者：
Ordemann, R;Hutchinson, R;Ferrara, JLM
通讯作者：
Ferrara, JLM
影响因子：
20.3
作者：
Blazar, BR;Taylor, PA;Vallera, DA
通讯作者：
Vallera, DA
影响因子：
3.6
作者：
Niculescu, F;Niculescu, T;Via, CS
通讯作者：
Via, CS
DOI：
10.4049/jimmunol.0803931
发表时间：
2009-03-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Nurieva R;Yang XO;Chung Y;Dong C
通讯作者：
Dong C