Myelin associated inhibitors: a link between injury-induced and experience-dependent plasticity.
Myelin associated inhibitors: a link between injury-induced and experience-dependent plasticity.
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DOI：
10.1016/j.expneurol.2011.06.006
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发表时间：
2012-05
影响因子：
5.3
通讯作者：
Strittmatter, Stephen M.
中科院分区：
文献类型：
--
作者：
Akbik, Feras;Cafferty, William B. J.;Strittmatter, Stephen M.
关键词：
在成年人中，CNS损伤后的神经恢复和解剖生长都是有限的。两类生长抑制剂，髓磷脂相关抑制剂（迈斯）和细胞外基质相关抑制剂，限制了脊髓损伤动物模型的功能恢复和解剖学重排。在这里，我们重点关注迈斯如何限制广泛的生长，包括再生，发芽和可塑性在完整的和受损的中枢神经系统。三种经典的髓磷脂相关抑制剂Nogo-A、MAG和OMgp通过其共同受体Nogo-66受体-1（NgR 1）和配对免疫球蛋白样受体-1（PirB）发出信号，以调节细胞骨架动力学并抑制生长。最初被描述为轴突再生的抑制剂，随后的研究表明，迈斯也限制了完整的成年CNS的活动和经验依赖性可塑性。因此，迈斯代表了可塑性的一个集中点，它限制了解剖学重排，而不管刺激是什么，模糊了损伤研究和更“基本”的可塑性研究之间的区别。
In the adult, both neurologic recovery and anatomical growth after a CNS injury are limited. Two classes of growth inhibitors, myelin associated inhibitors (MAIs) and extracellular matrix associated inhibitors, limit both functional recovery and anatomical rearrangements in animal models of spinal cord injury. Here we focus on how MAIs limit a wide spectrum of growth that includes regeneration, sprouting, and plasticity in both the intact and lesioned CNS. Three classic myelin associated inhibitors, Nogo-A, MAG, and OMgp, signal through their common receptors, Nogo-66 Receptor-1 (NgR1) and Paired-Immunoglobulin-like-Receptor-1 (PirB), to regulate cytoskeletal dynamics and inhibit growth. Initially described as inhibitors of axonal regeneration, subsequent work has demonstrated that MAIs also limit activity and experience-dependent plasticity in the intact, adult CNS. MAIs therefore represent a point of convergence for plasticity that limits anatomical rearrangements regardless of the inciting stimulus, blurring the distinction between injury studies and more “basic” plasticity studies.
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抗Nogo-A抗体治疗促进成年灵长类单侧颈椎损伤后手灵巧度的恢复——行为数据的重新检查和扩展。
DOI：
10.1111/j.1460-9568.2009.06642.x
发表时间：
2009-03
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Freund P;Schmidlin E;Wannier T;Bloch J;Mir A;Schwab ME;Rouiller EM
通讯作者：
Rouiller EM
影响因子：
5.3
作者：
Fournier, AE;Takizawa, BT;Strittmatter, SM
通讯作者：
Strittmatter, SM
影响因子：
5.3
作者：
Coumans, JV;Lin, TTS;Bregman, BS
通讯作者：
Bregman, BS
影响因子：
2.5
作者：
BARTSCH, U;KIRCHHOFF, F;SCHACHNER, M
通讯作者：
SCHACHNER, M
DOI：
10.1016/s0003-9993(97)90326-9
发表时间：
1997-11-01
影响因子：
4.3
作者：
Burns, SP;Golding, DG;Ditunno, JF
通讯作者：
Ditunno, JF