Cohort-profile: Household transmission of SARS-CoV-2 in a low-resource community in Rio de Janeiro, Brazil.
Cohort-profile: Household transmission of SARS-CoV-2 in a low-resource community in Rio de Janeiro, Brazil.
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DOI：
10.1136/bmjopen-2022-067212
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发表时间：
2022-12-07
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
为了更好地了解COVID-19大流行期间（2020-2022年）里约热内卢低资源社区SARS-COV-2的家庭传播。这是一项在≤12岁儿童及其家庭接触者中开展的开放性前瞻性队列研究。在超过24个月的家访中，我们收集了有关社会人口学特征、行为数据、SARS-CoV-2临床表现、疫苗接种状况、SARS-CoV-2（逆转录-聚合酶链反应）RT-PCR和抗S抗体检测的数据。在成年人中，大多数参与者是女性（62%）。我们于2020年5月至2022年5月招募了845个家庭。平均每户居民人数为4人。住户密度中位数，即每个房间的人数，为0.95人。每间客房人数较多的家庭发生SARS-CoV-2的风险较高。在第一波大流行期间，儿童不是家庭中SARS-CoV-2感染的主要来源。未来的研究将调查局部循环SARS-CoV-2变异体的细胞和体液免疫应答，这与疫苗，抗病毒药物和单克隆抗体的设计有关。我们还将开展外联活动，鼓励接种疫苗，以此作为限制新型SARS-CoV-2变异体和其他新出现病原体传播的一种手段。
To better understand the household transmission of SARS-COV-2 in a low-resource community in Rio de Janeiro during the COVID-19 pandemic (2020–2022). This is an open prospective cohort study of children ≤12 years old and their household contacts. During home visits over 24 months, we collected data on sociodemographic characteristics, behavioural data, clinical manifestations of SARS-CoV-2, vaccination status, SARS-CoV-2 (reverse transcription-polymerase chain reaction) RT-PCR and anti-S antibody tests. Among adults, the majority of participants were women (62%). We enrolled 845 families from May 2020 to May 2022. The median number of residents per household was four. The median household density, defined as the number of persons per room, was 0.95. The risk of SARS-CoV-2 occurrence was higher in households with a high number of persons per room. Children were not the principal source of SARS-CoV-2 infections in their households during the first wave of the pandemic. Future studies will investigate cellular and humoral immune responses to locally circulating SARS-CoV-2 variants, which is relevant for the design of vaccines, antivirals and monoclonal antibodies. We will also engage in outreach to encourage vaccination as a means of limiting the transmission of novel SARS-CoV-2 variants and other emerging pathogens.
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影响因子：
8
作者：
Lugon P;Fuller T;Damasceno L;Calvet G;Resende PC;Matos AR;Machado Fumian T;Malta FC;Salgado AD;Fernandes FCM;Abreu de Carvalho LM;Guaraldo L;Bastos L;Cruz OG;Whitworth J;Smith C;Nielsen-Saines K;Siqueira M;Carvalho MS;Brasil P
通讯作者：
Brasil P
影响因子：
8.4
作者：
de Aguiar, Daniele Fernandes;de Barros, Eliana Nogueira C.;de Noronha, Tatiana Guimaraes
通讯作者：
de Noronha, Tatiana Guimaraes
DOI：
10.1056/nejmoa1602412
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brasil P;Pereira JP Jr;Moreira ME;Ribeiro Nogueira RM;Damasceno L;Wakimoto M;Rabello RS;Valderramos SG;Halai UA;Salles TS;Zin AA;Horovitz D;Daltro P;Boechat M;Raja Gabaglia C;Carvalho de Sequeira P;Pilotto JH;Medialdea-Carrera R;Cotrim da Cunha D;Abreu de Carvalho LM;Pone M;Machado Siqueira A;Calvet GA;Rodrigues Baião AE;Neves ES;Nassar de Carvalho PR;Hasue RH;Marschik PB;Einspieler C;Janzen C;Cherry JD;Bispo de Filippis AM;Nielsen-Saines K
通讯作者：
Nielsen-Saines K
影响因子：
8.4
作者：
Amzat, Jimoh;Aminu, Kafayat;Danjibo, Maryann C.
通讯作者：
Danjibo, Maryann C.
影响因子：
5.2
作者：
Resende PC;Delatorre E;Gräf T;Mir D;Motta FC;Appolinario LR;da Paixão ACD;Mendonça ACDF;Ogrzewalska M;Caetano B;Wallau GL;Docena C;Dos Santos MC;de Almeida Ferreira J;Sousa Junior EC;da Silva SP;Fernandes SB;Vianna LA;Souza LDC;Ferro JFG;Nardy VB;Santos CA;Riediger I;do Carmo Debur M;Croda J;Oliveira WK;Abreu A;Bello G;Siqueira MM
通讯作者：
Siqueira MM